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DNA repair

Damage alert

Nature volume 421, pages 486–488 (2003)Cite this article

Radiation and other harmful influences frequently damage our genes, potentially causing diseases such as cancer. New work reveals a surprising mechanism that notifies the cellular defence system about DNA damage.

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Figure 1: Arming cells to respond to DNA damage.

References

  1. Hoeijmakers, J. H. J. Nature 411, 366–374 (2001).

    Article  ADS  CAS  Google Scholar 

  2. Bakkenist, C. J. & Kastan, M. B. Nature 421, 499–506 (2003).

    Article  ADS  CAS  Google Scholar 

  3. Shiloh, Y. Curr. Opin. Genet. Dev. 11, 71–77 (2001).

    Article  CAS  Google Scholar 

  4. Kastan, M. B. & Lim, D.-S Nature Rev. Mol. Cell Biol. 1, 179–186 (2000).

    Article  CAS  Google Scholar 

  5. Abraham, R. T. Genes Dev. 15, 2177–2196 (2001).

    Article  CAS  Google Scholar 

  6. Zhou, B.-B S. & Elledge, S. J. Nature 408, 433–439 (2000).

    Article  ADS  CAS  Google Scholar 

  7. Wahl, G. M. & Carr, A. M. Nature Cell Biol. 3, 277–286 (2001).

    Article  Google Scholar 

  8. Lukas, C. et al. Cancer Res. 61, 4990–4993 (2001).

    CAS  Google Scholar 

  9. Wolffe, A. P. & Guschin, D. J. Struct. Biol. 129, 102–122 (2000).

    Article  CAS  Google Scholar 

  10. Koyama, H., Itoh, M., Miyahara, K. & Tsuchiya, E. FEBS Lett. 531, 215–221 (2002).

    Article  CAS  Google Scholar 

  11. Rouse, J. & Jackson, S. P. Science 297, 547–551 (2002).

    Article  ADS  CAS  Google Scholar 

  12. Shimada, K., Pasero, P. & Gasser, S. M. Genes Dev. 16, 3236–3252 (2002).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. the Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, Copenhagen, DK-2100, Denmark

    Jiri Bartek & Jiri Lukas

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  1. Jiri Bartek
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  2. Jiri Lukas
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Correspondence to Jiri Bartek.

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Bartek, J., Lukas, J. Damage alert. Nature 421, 486–488 (2003). https://doi.org/10.1038/421486a

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