Immune cells must be taught to distinguish between invading microbes and the body's own proteins. A new study re-emphasizes the importance of a thorough education in the thymus, and identifies an essential instructor.
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References
Anderson, M. S. et al. Science 298, 1395–1401 (2002).
Nagamine, K. et al. Nature Genet. 17, 393–398 (1997).
The Finnish–German APECED Consortium Nature Genet. 17, 399–403 (1997).
Ahonen, P. Clin. Genet. 27, 535–542 (1985).
Bjorses, P. et al. Am. J. Hum. Genet. 66, 378–392 (2000).
Kumar, P. G. et al. J. Biol. Chem. 276, 41357–41364 (2001).
Heino, M. et al. Biochem. Biophys. Res. Commun. 257, 821–825 (1999).
Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Nature Immunol. 2, 1032–1039 (2001).
Hanahan, D. Curr. Opin. Immunol. 10, 656–662 (1998).
Ramsey, C. et al. Hum. Mol. Genet. 11, 397–409 (2002).
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Heath, W., Scott, H. Education and promiscuity. Nature 420, 468–469 (2002). https://doi.org/10.1038/420468a
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DOI: https://doi.org/10.1038/420468a
