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Human genetics

Mystery of the mutagenic male

Old fathers are the source of more genetic mutations in their offspring than either young fathers or mothers of any age. But the apparently most plausible explanation for this effect might not hold.

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Figure 1: Sperm — not guilty?

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Hurst, L., Ellegren, H. Mystery of the mutagenic male. Nature 420, 365–366 (2002). https://doi.org/10.1038/420365a

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