Chromosomes adopt their well-known form only at a certain phase in the cell-division cycle, just before they separate. But the proteins that help shape chromosomes also seem to be at work earlier on.
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Uhlmann, F. Keeping the genome in shape. Nature 417, 135–136 (2002). https://doi.org/10.1038/417135a
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DOI: https://doi.org/10.1038/417135a