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Meta-analysis of two dopamine D2 receptor gene polymorphisms with tardive dyskinesia in schizophrenia patients

Molecular Psychiatry volume 12, pages 794–795 (2007)Cite this article

Tardive dyskinesia (TD) is a potentially irreversible movement disorder related to chronic antipsychotic medication exposure. The etiology is unknown, though genetic factors are likely contributors.1 Although the dopamine D2 receptor has been recognized as the main target for antipsychotics, studies investigating potential involvement of D2 gene (DRD2) polymorphisms in TD have yielded mixed results.2 Of these polymorphisms, TaqIA and −141C Ins/Del, have been studied most extensively.

The −141C Del allele has been reported to decrease DRD2 promoter activity in vitro, while two in vivo studies showed the Del allele to be associated either with an increase in striatal D2 binding or with no significant difference.2 The Taq1A polymorphism was recently discovered to reside in the coding region of an overlapping gene coding for a serine/threonine kinase, and cause an amino-acid change.2 However, the A1 (T) allele has been associated with reduced D2 levels in most reported studies.2

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Authors and Affiliations

  1. Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada

    C C Zai, V De Luca, R W Hwang, A Voineskos, D J Müller, G Remington & J L Kennedy

  2. Department of Psychiatry, Institute of Medical Science, University of Toronto, Toronto, ON, Canada

    C C Zai, V De Luca, R W Hwang, A Voineskos & J L Kennedy

  3. Department of Psychiatry, Charité University Medicine Berlin, Charité Campus Mitte, Berlin, Germany

    D J Müller

Authors
  1. C C Zai
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  2. V De Luca
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  3. R W Hwang
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  4. A Voineskos
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  5. D J Müller
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  6. G Remington
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  7. J L Kennedy
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Correspondence to J L Kennedy.

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Zai, C., De Luca, V., Hwang, R. et al. Meta-analysis of two dopamine D2 receptor gene polymorphisms with tardive dyskinesia in schizophrenia patients. Mol Psychiatry 12, 794–795 (2007). https://doi.org/10.1038/sj.mp.4002023

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