Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Decreased circulating CD34+ stem cells in early Alzheimer's disease: evidence for a deficient hematopoietic brain support?

Molecular Psychiatry volume 11, pages 1113–1115 (2006)Cite this article

Abstract

Hematopoietic stem cells contribute to mammalian brain tissue regeneration by transdifferentiation processes. We found decreased counts of circulating CD34+ cells in early Alzheimer's dementia (AD; P=0.01), which significantly correlated with age (r=−0.661; P=0.001), cerebrospinal fluid β-amyloid (Aβ)1–42 (r=−0.467; P=0.025) and most pronounced the Aβ42/40 ratio (r=−0.688; P=0.005). Our data suggest a deficient regenerative hematopoietic support for the central nervous system in early AD.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. DeKosky ST, Scheff SW, Styren SD . Structural correlates of cognition in dementia: quantification and assessment of synapse change. Neurodegeneration 1996; 5: 417–421.

    Article  CAS  Google Scholar 

  2. Kuhn HG, Dickinson-Anson H, Gage FH . Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci 1996; 16: 2027–2033.

    Article  CAS  Google Scholar 

  3. Rice AC, Khaldi A, Harvey HB, Salman NJ, White F, Fillmore H et al. Proliferation and neuronal differentiation of mitotically active cells following traumatic brain injury. Exp Neurol 2003; 183: 406–417.

    Article  CAS  Google Scholar 

  4. Kempermann G, Brandon EP, Gage FH . Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus. Curr Biol 1998; 8: 939–942.

    Article  CAS  Google Scholar 

  5. Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR . Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000; 290: 1779–1782.

    Article  CAS  Google Scholar 

  6. Cogle CR, Yachnis AT, Laywell ED, Zander DS, Wingard JR, Steindler DA et al. Bone marrow transdifferentiation in brain after transplantation: a retrospective study. Lancet 2004; 363: 1432–1437.

    Article  CAS  Google Scholar 

  7. Sigurjonsson OE, Perreault MC, Egeland T, Glover JC . Adult human hematopoietic stem cells produce neurons efficiently in the regenerating chicken embryo spinal cord. Proc Natl Acad Sci USA 2005; 102: 5227–5232.

    Article  CAS  Google Scholar 

  8. Paczkowska E, Larysz B, Rzeuski R, Karbicka A, Jalowinski R, Kornacewicz-Jach Z et al. Human hematopoietic stem/progenitor-enriched CD34(+) cells are mobilized into peripheral blood during stress related to ischemic stroke or acute myocardial infarction. Eur J Haematol 2005; 75: 461–467.

    Article  CAS  Google Scholar 

  9. Shyu WC, Lin SZ, Chiang MF, Su CY, Li H . Intracerebral peripheral blood stem cell (CD34+) implantation induces neuroplasticity by enhancing beta1 integrin-mediated angiogenesis in chronic stroke rats. J Neurosci 2006; 26: 3444–3453.

    Article  CAS  Google Scholar 

  10. Wiltfang J, Lewczuk P, Riederer P, Grunblatt E, Hock C, Scheltens P et al. Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia. World J Biol Psychiatry 2005; 6: 69–84.

    Article  CAS  Google Scholar 

  11. Lewczuk P, Esselmann H, Otto M, Maler JM, Henkel AW, Henkel MK et al. Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau. Neurobiol Aging 2004; 25: 273–281.

    Article  CAS  Google Scholar 

  12. Fritsch G, Buchinger P, Printz D, Fink FM, Mann G, Peters C et al. Rapid discrimination of early CD34+ myeloid progenitors using CD45-RA analysis. Blood 1993; 81: 2301–2309.

    PubMed  CAS  Google Scholar 

  13. Kuo YM, Emmerling MR, Vigo-Pelfrey C, Kasunic TC, Kirkpatrick JB, Murdoch GH et al. Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. J Biol Chem 1996; 271: 4077–4081.

    Article  CAS  Google Scholar 

  14. Simard AR, Soulet D, Gowing G, Julien JP, Rivest S . Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 2006; 49: 489–502.

    Article  CAS  Google Scholar 

  15. Chen CW, Boiteau RM, Lai WF, Barger SW, Cataldo AM . sAPPalpha enhances the transdifferentiation of adult bone marrow progenitor cells to neuronal phenotypes. Curr Alzheimer Res 2006; 3: 63–70.

    Article  CAS  Google Scholar 

  16. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001; 89: E1–E7.

    Article  CAS  Google Scholar 

  17. Sjogren M, Blennow K . The link between cholesterol and Alzheimer's disease. World J Biol Psychiatry 2005; 6: 85–97.

    Article  Google Scholar 

  18. Kucia M, Ratajczak J, Reca R, Janowska-Wieczorek A, Ratajczak MZ . Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury. Blood Cells Mol Dis 2004; 32: 52–57.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported in part by grants from the Interdisciplinary Center for Clinical Research, Erlangen, Germany, and from the German Federal Ministry of Education and Research (HBPP-NGFN2; 01 GR 0447). We thank U Reulbach for statistical support.

Author information

Author notes

  1. M Herrmann and J Wiltfang: These authors have contributed equally to this work.

Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany

    J M Maler, P Spitzer, P Lewczuk, J Kornhuber & J Wiltfang

  2. Department of Medicine III, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    M Herrmann

Authors
  1. J M Maler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P Spitzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P Lewczuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Kornhuber
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M Herrmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J Wiltfang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J Wiltfang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maler, J., Spitzer, P., Lewczuk, P. et al. Decreased circulating CD34+ stem cells in early Alzheimer's disease: evidence for a deficient hematopoietic brain support?. Mol Psychiatry 11, 1113–1115 (2006). https://doi.org/10.1038/sj.mp.4001913

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.mp.4001913

Keywords

This article is cited by

Search

Advanced search

Quick links