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A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12

Molecular Psychiatry volume 10, pages 545–552 (2005)Cite this article

Abstract

Our previous results pointed to a putative gene for susceptibility to bipolar affective disorder located on the chromosomal region 12q23–q24 that segregated in the Saguenay-Lac-St-Jean population of Quebec. We report here results from a second genome-wide scan based on the analysis of 380 polymorphic microsatellite markers. For the purpose of this analysis, an additional 18 families were recruited from the Saguenay-Lac-St-Jean region and pooled to our previous sample to improve its statistical power, giving a total of 394 sampled individuals. This work confirms the presence of a susceptibility locus for affective disorder on chromosome 12q24 with parametric LOD score value of 3.35 at D12S378 when pedigrees were broken into nuclear families and analysed under a recessive segregation model. This result was supported by neighbouring markers and by a LOD score value of 5.05 at D12S378 under model-free analysis. Other regions of lower interest were indicated on chromosomes 2, 5, 7, 9, 10, 17 and 20.

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Acknowledgements

We thank all patients and families for participating in the study. This work was supported in part by the Canadian Institutes of Health Research and Axys Pharmaceuticals Inc.

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Authors and Affiliations

  1. Neuroscience, CHUL Research Centre and Laval University, CHUQ Pavillon CHUL, Ste-Foy, Québec, Canada

    E Shink & N Barden

  2. Bioinformatics, CHUL Research Centre and Laval University, CHUQ Pavillon CHUL, Ste-Foy, Québec, Canada

    J Morissette

  3. Axys Pharmaceuticals Inc., South San Francisco, CA, USA

    R Sherrington

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Correspondence to N Barden.

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Shink, E., Morissette, J., Sherrington, R. et al. A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12. Mol Psychiatry 10, 545–552 (2005). https://doi.org/10.1038/sj.mp.4001601

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