This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Suzuki N et al. Science 1994; 264: 1336–1340.
Duff K et al. Nature 1996; 383: 710–713.
Iwatsubo T et al. Neuron 1994; 13: 45–53.
De Strooper B et al. Nature 1998; 391: 387–390.
Wolfe MS et al. Nature 1999; 398: 513–517.
Li YM et al. Nature 2000; 405: 689–694.
Yu G et al. Nature 2000; 407: 48–54.
Goutte C . Proc Natl Acad Sci USA 2002; 99: 775–779.
Francis R et al. Dev Cell 2002; 3: 85–97.
Takasugi N et al. Nature 2003; 422: 438–441.
LaVoie MJ et al. J Biol Chem 2003; 278: 37213–37222.
Edbauer D et al. Nat Cell Biol 2003; 5: 486–488.
Kim SH et al. J Biol Chem 2003; 278: 33992–34002.
Acknowledgements
We thanks Drs Michael C Irizarry and Taisuke Tomita for valuable comments on the manuscript.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Iwatsubo, T. Assembly and activation of the γ-secretase complex: roles of presenilin cofactors. Mol Psychiatry 9, 8–10 (2004). https://doi.org/10.1038/sj.mp.4001438
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.mp.4001438
This article is cited by
-
Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis
Molecular Neurobiology (2013)