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What's new in epilepsy genetics?

Molecular Psychiatry volume 8, pages 463–465 (2003)Cite this article

Episodic diseases are among the most common to afflict the nervous system. They include migraine headache and epilepsy, which take a great toll on those suffering from these ailments. Genetic contributions to disorders such as epilepsy and migraine are well known, although they are very complex. Understanding the complex genetic milieu of migraine and epilepsy pathogenesis is further confounded by environmental influences that have dramatic effects on the expression of these phenotypes.

One approach to studying complex disorders is through study of a subset of these disorders in which the phenotype is segregating as a Mendelian trait. Such disorders are more amenable to molecular characterization and may provide insights into possible genetic contributions to the complex forms of these disorders.

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Authors and Affiliations

  1. Departments of Neurology and Human Genetics, Howard Hughes Medical Institute, University of Utah, UT, USA

    Louis J Ptácek

  2. Department of Neurology, University of California at San Francisco, San Francisco, CA, USA

    Ying-Hui Fu

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  1. Louis J Ptácek
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  2. Ying-Hui Fu
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Correspondence to Louis J Ptácek.

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Ptácek, L., Fu, YH. What's new in epilepsy genetics?. Mol Psychiatry 8, 463–465 (2003). https://doi.org/10.1038/sj.mp.4001292

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