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A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes

Molecular Psychiatry volume 6, pages 684–693 (2001)Cite this article

Abstract

We report the first stage of a genome scan of schizophrenia (SZ) and bipolar disorder (BP) covering 18 candidate chromosomal areas. In addition to testing susceptibility loci that are specific to each disorder, we tested the hypothesis that some susceptibility loci might be common to both disorders. A total of 480 individuals from 21 multigenerational pedigrees of Eastern Québec were evaluated by means of a consensus best-estimate diagnosis made blind to diagnoses in relatives and were genotyped with 220 microsatellite markers. Two-point and multipoint model-based linkage analyses were performed and mod scores (Z, for max Zmax) are reported. The strongest linkage signals were detected at D18S1145 (in 18q12; Z = 4.03) for BP, and at D6S334 (in 6p 22–24; Zhet = 3.47; α = 0.66) for SZ. Three other chromosomal areas (3q, 10p, and 21q) yielded linkage signals. Chromosomes 3p, 4p, 5p, 5q, 6q, 8p, 9q, 11q, 11p, 12q, 13q, 18p and 22q showed no evidence of linkage. The 18q12 results met the Lander and Kruglyak (1995) criterion for a genome-wide significant linkage and suggested that this susceptibility region may be shared by SZ and BP. The 6p finding provided confirmatory evidence of linkage for SZ. Our results suggest that both specific and common susceptibility loci must be searched for SZ and BP.

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Acknowledgements

Supported in part by a group grant from the Medical Research Council of Canada, No. GR-14501, by the Fonds de la recherche en santé du Québec scholarships (Roy and Mérette), and by the Chaire de psychiatrie de l'Université Laval.

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Authors and Affiliations

  1. Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, G1J 2G3, Québec, Canada

    M Maziade, M-A Roy, É Rouillard, L Bissonnette, J-P Fournier, A Roy, Y Garneau, N Montgrain, A Potvin, D Cliche, C Dion, H Wallot, A Fournier, L Nicole, J-C Lavallée & C Mérette

  2. Department of Psychiatry, Faculty of Medicine, Université Laval, Sainte-Foy, G1K 7P4, Québec, Canada

    M Maziade, M-A Roy, Y Garneau, N Montgrain, A Potvin, H Wallot, L Nicole & C Mérette

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Correspondence to M Maziade.

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Maziade, M., Roy, MA., Rouillard, É. et al. A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes. Mol Psychiatry 6, 684–693 (2001). https://doi.org/10.1038/sj.mp.4000915

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