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Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity

Molecular Psychiatry volume 6, pages 586–592 (2001)Cite this article

Abstract

The aim of the present study was to test a possible effect of the A218C tryptophan hydroxylase (TPH) gene variant on the antidepressant activity of fluvoxamine in a sample of major and bipolar depressives, with or without psychotic features. Two hundred and seventeen inpatients were treated with fluvoxamine 300?mg and either placebo or pindolol in a double blind design for 6 weeks. The severity of depressive symptoms was weekly assessed with the Hamilton Rating Scale for Depression. TPH allelic variants were determined in each subject by using a PCR-based technique. No significant finding was observed in the overall sample as well as in the pindolol group, while TPH*A/A was associated with a slower response to fluvoxamine treatment in subjects not taking pindolol (P = 0.001). This effect was independent from the previously reported influence of 5-HTTLPR polymorphism. If confirmed, these results may shed further light on the genetically determined component of the response to pharmacological treatments, thus helping the clinician to individualize each patient's therapy according to their genetic pattern.

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Acknowledgements

This study was supported by Istituto Scientifico Ospedale. San Raffaele (grants M0975 and M2511). The authors acknowledge Cristina Lorenzi for her help with DNA analysis and Enrico Lattuada MD for collecting blood samples.

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Authors and Affiliations

  1. Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy

    A Serretti, R Zanardi, D Rossini, C Cusin, R Lilli & E Smeraldi

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  1. A Serretti
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Correspondence to A Serretti or R Zanardi.

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Serretti, A., Zanardi, R., Rossini, D. et al. Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity. Mol Psychiatry 6, 586–592 (2001). https://doi.org/10.1038/sj.mp.4000876

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