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  • Cytokines in the Brain
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Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue

Molecular Psychiatry volume 2, pages 133–136 (1997)Cite this article

Abstract

A profound inflammatory response is initiated immediately following traumatic brain injury (TBI) and is characterized by the release of several cytokines with pro- and anti-inflammatory functions. In order to elucidate which cytokines are released in the human brain in response to injury as well as in the peripheral compartment, IL-1, IL-6, IL-8, IL-10, TNF-α and TGF-β were monitored in CSF and serum of severely brain-injured patients. Furthermore, we investigated the possible modulation of systemic reactions by IL-6 and the ability of IL-6 and IL-8 to promote the synthesis of nerve growth factor.

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Authors and Affiliations

  1. Department of Surgery, Division of Research, University Hospital, Zürich, 8091, Switzerland

    M C Morganti-Kossman, P M Lenzlinger, V Hans, E Csuka & E Ammann

  2. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

    P Stahel

  3. Division of Trauma Surgery, University Hospital, Zürich, 8091, Switzerland

    R Stocker, O Trentz & T Kossmann

Authors
  1. M C Morganti-Kossman
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  2. P M Lenzlinger
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  3. V Hans
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  4. P Stahel
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  5. E Csuka
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  6. E Ammann
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  7. R Stocker
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  8. O Trentz
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  9. T Kossmann
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Morganti-Kossman, M., Lenzlinger, P., Hans, V. et al. Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue. Mol Psychiatry 2, 133–136 (1997). https://doi.org/10.1038/sj.mp.4000227

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  • DOI: https://doi.org/10.1038/sj.mp.4000227

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