Abstract
A total of 400 male renal transplant recipients (RTR) were investigated. Data on medical, sexual history, clinical examination and laboratory variables were collected. The severity of erectile dysfunction (ED) was assessed using the International Index of Erectile Function questionnaire. Univariate and multivariate logistic regression analyses were used to determine prognostic variables, which have independent impact on erectile function. ED was detected in 35.8% of the whole group. Current erectile function as compared to pretransplant status was improved, deteriorated or remained static in 44, 12.5 and 43.5% of the evaluated transplant recipients, respectively. After logistic regression analysis, age, hemoglobin level and presence of DM and/or peripheral neuropathy had significant and independent negative impact on erectile function. We concluded that renal transplantation has varying effects on erectile function. ED is highly prevalent among RTR and its pathogenesis is multifactorial.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 8 print issues and online access
$259.00 per year
only $32.38 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Sherman JP . Impotence in patients with chronic renal failure on dialysis: its frequency and etiology. Fertil Steril 1975; 26: 221–223.
Cerqueira J, Moraes M, Glina S . Erectile dysfunction: prevalence and associated variables in patients with chronic renal failure. Int J Impot Res 2002; 14: 65–71.
Carson CC, Krishnan R . Chronic renal failure and sexual dysfunction. In: Carson CC, Kirby R, Goldstein I (eds). Text Book of Erectile Dysfunction. Ibis Medical Media: Oxford, 1999, pp 31–41.
Salvatierra O, Fortmann JL, Belzer FO . Sexual function in males before and after renal transplantation. Urology 1975; 5: 64–66.
Flechner SM et al. Functional capacity and rehabilitation of recipients with a functioning renal allograft for ten years or more. Transplantation 1983; 35: 572–576.
Saha MT . Time course of serum prolactin and sex hormones following successful renal transplantation. Nephron 2002; 92: 735–737.
Charmer GP . Sexual function in dialysis patients: psychological aspects. Contrib Nephrol 1990; 77: 15–24.
Diemont WL et al. Sexual dysfunction after renal replacement therapy. Am J Kid Dis 2000; 35: 845–851.
Malavaud B et al. High prevalence of erectile dysfunction after renal transplantation. Transplantation 2000; 69: 2121–2124.
Truss M et al. Transplantation and erectile dysfunction—is there a causative relationship? Int J Impot Res 1992; 4: 103–108.
Peskircioglu L et al. Evaluation of erectile function in renal transplant recipients. Transplant Proc 1998; 30: 747–749.
Brannen GE et al. Impotence after kidney transplantation. Urology 1980; 15: 138–146.
Nghiem D, Corry R, Picon-Mendez G, Lee H . Factors influencing male sexual impotence after renal transplantation. Urology 1983; 21: 49–52.
Rosen R et al. The International Index of Erectile Dysfunction (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822–830.
Dillard FT et al. Erectile dysfunction post-transplant. Transplant Proc 1989; 21: 3961–3969.
Espinoza R, Melchor JI, Gracida C . Sildenafil in kidney transplant recipients with erectile dysfunction. Transplant Proc 2002; 34: 408–409.
Kinsey AC, Pomeroy WB, Martin CE . Sexual Behavior in the Human Male. WB Saunders: Philadelphia, 1984, 218 pp.
Feldman HA et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 151–154.
Abdel-Hamid I, Eraky I, Fouda M, Mansour O . Role of penile vascular insufficiency in erectile dysfunction in renal transplant recipients. Int J Impot Res 2002; 14: 32–37.
Kaufman JM et al. Impotence and chronic renal failure: a study of the hemodynamic pathophysiology. J Urol 1994; 151: 612–618.
Lundberg PO, Biriell C . Impotence—the drug risk factor. Int J Impot Res 1993; 5: 237–239.
Kim N et al. Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection. J Clin Invest 1993; 91: 437–442.
Falanga V et al. Hypoxia upregulates the synthesis of TGF-B1 by human dermal fibroblasts. J Invest Dermatol 1991; 97: 634–637.
Azadzoi KM, De Tejada IS . Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol 1990; 146: 238–240.
Azadzoi KM et al. Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction. J Urol 1998; 160: 2216–2222.
Oriji GK, Keiser HR . Role of nitric oxide in cyclosporine A induced hypertension. Hypertension 1998; 32: 849–855.
Morris S et al. Endothelial dysfunction in renal transplant recipients maintained on cyclosporine. Kidney Int 2000; 57: 1100–1106.
Esposito C et al. Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell cultures. Kidney Int 2000; 85: 123–130.
Shihab FS, Yi H, Bennett WM, Andoh TF . Effect of nitric oxide modulation on TGFβ1 and matrix proteins in chronic cyclosporine nephrotoxicity. Kidney Int 2000; 58: 1174–1185.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
El-Bahnasawy, M., El-Assmy, A., El-Sawy, E. et al. Critical evaluation of the factors influencing erectile function after renal transplantation. Int J Impot Res 16, 521–526 (2004). https://doi.org/10.1038/sj.ijir.3901222
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ijir.3901222
Keywords
This article is cited by
-
The impact of renal transplantation on sexual function in males with end-stage kidney disease: a systematic review and meta-analysis
International Urology and Nephrology (2022)
-
Prevalence of erectile dysfunction in patients with chronic kidney disease: a systematic review and meta-analysis
International Journal of Impotence Research (2021)
-
Does kidney transplantation onto the external iliac artery affect the haemodynamic parameters of the cavernosal arteries?
Asian Journal of Andrology (2012)
-
Analyse du statut spermatique, érectile et hormonal chez des patients hémodialysés
Basic and Clinical Andrology (2011)