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Release of gelatinase A during platelet activation mediates aggregation

Nature volume 386, pages 616–619 (1997)Cite this article

Abstract

Blood platelets limit blood loss at sites of vascular injury by forming a mechanical plug. They are also involved in thrombosis, atherosclerosis, inflammation and metastasis. Platelet activation is essential for these physiological and pathological reactions and depends upon their adhesion to the vessel wall and attachment to each other in the aggregation process. The two known pathways of aggregation are mediated by the release of endoperoxides/throm-boxane A2 and ADP1–3 which amplify platelet aggregation. Here we report the identification of a new pathway of aggregation which is mediated by the release of a metalloproteinase enzyme, gelatinase A.

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Authors and Affiliations

  1. Departments of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada

    Grzegorz Sawicki, Eduardo Salas, Jesus Murat, Helena Miszta-Lane & Marek W. Radomski

  2. Obstetrics and Gynaecology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada

    Marek W. Radomski

Authors
  1. Grzegorz Sawicki
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  2. Eduardo Salas
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  4. Helena Miszta-Lane
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  5. Marek W. Radomski
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Sawicki, G., Salas, E., Murat, J. et al. Release of gelatinase A during platelet activation mediates aggregation. Nature 386, 616–619 (1997). https://doi.org/10.1038/386616a0

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