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In search of molecular darwinism

Attempts to detect adaptive evolution at the molecular level have met with little success. Studies of a digestive enzyme in primates, involving the reconstruction of DNA sequences that have long been extinct, show a way forward.

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References

  1. Haldane, J. B. S. in On Being the Right Size (ed. Maynard Smith, J.) 13–25 (Oxford Univ. Press, 1985).

    Google Scholar 

  2. Stewart, C.-B., Schilling, J. W. & Wilson, A. C. Nature 330, 401–404 (1986).

    Article  ADS  Google Scholar 

  3. Messier, W. & Stewart, C.-B. Nature 385, 151–154 (1997).

    Article  ADS  CAS  Google Scholar 

  4. Wolfe, K. H. & Sharp, P. M. J. Molec. Evol. 37, 441–456 (1993).

    Article  ADS  CAS  Google Scholar 

  5. Hughes, A. L. & Nei, M. Nature 335, 167–170 (1988).

    Article  ADS  CAS  Google Scholar 

  6. McDonald, J. H. & Kreitman, M. Nature 351, 652–654 (1991).

    Article  ADS  CAS  Google Scholar 

  7. Jenkins, D. L., Ortori, C. A. & Brookfield, J. F. Y. Proc. R. Soc. Lond. B 261, 203–207 (1995).

    Article  ADS  CAS  Google Scholar 

  8. Li, W.-H. & Graur, D. Fundamentals of Molecular Evolution (Sinauer, Sunderland, MA, 1991).

    Google Scholar 

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Sharp, P. In search of molecular darwinism. Nature 385, 111–112 (1997). https://doi.org/10.1038/385111a0

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