Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

Graham V. Williams; Patricia S. Goldman-Rakic

doi:10.1038/376572a0

Abstract

Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

Rent or Buy

All prices are NET prices.

References

1.
Bradley, V. A., Welch, J. L. & Dick, D. J. J. Neurol. Neurosurg. Psychiat. 52, 1228–1235 (1989).
2.
Park, S. & Holzman, P. S. Archs gen. Psychiat. 49, 975–982 (1992).
- - CAS
  - Google Scholar
3.
Goldman-Rakic, P. S. in Psychopathology and the Brain (eds Carroll, B. J. & Barrett, J. E.) 1–23 (Am. psychopath. Ass. & Raven, New York, 1991).
- - Google Scholar
4.
Brozoski, T. J., Brown, R. M., Rosvold, H. E. & Goldman, P. S. Science 205, 929–932 (1979).
5.
Daniel, D. G. et al. J. Neurosci. 11, 1907–1917 (1991).
6.
Lange, K. W. et al. Psychopharmacology 107, 394–404 (1992).
7.
Seeman, P. Synapse 1, 133–152 (1987).
8.
Sawaguchi, T. & Goldman-Rakic, P. S. Science 251, 947–950 (1991).
9.
Arnsten, A. F. T., Cai, J. X., Murphy, B. L. & Goldman-Rakic, P. S. Psychopharmacology 116, 143–151 (1994).
10.
Lidow, M. S., Goldman-Rakic, P. S., Gallager, D. W. & Rakic, P. Neuroscience 40, 657–671 (1991).
11.
Cepeda, C. et al. Synapse 11, 330–341 (1992).
12.
Cepeda, C., Buchwald, N. A. & Levine, M. S. Proc. natn. Acad. Sci. U.S.A. 90, 9576–9580 (1993).
- - CAS
  - Google Scholar
13.
Funahashi, S., Bruce, C. J. & Goldman-Rakic, P. S. J. Neurophysiol. 61, 331–349 (1989).
14.
O'Scalaidhe, S. P. & Goldman-Rakic, P. S. Soc. Neurosci. Abstr. 19, 800 (1993).
- - Google Scholar
15.
Funahashi, S., Bruce, C. J. & Goldman-Rakic, P. S. J. Neurophysiol. 63, 814–831 (1990).
16.
Drago, J. et al. Proc. natn. Acad. Sci. U.S.A. 91, 12564–12568 (1994).
- - CAS
  - Google Scholar
17.
Xu, M. et al. Cell 79, 945–955 (1994).
18.
Chipkin, R. E. et al. J. Pharmac. exp. Ther. 247, 1093–1102 (1988).
- - CAS
  - Google Scholar
19.
Taylor, L. A., Tedford, C. E. & McQuade, R. D. Life Sci. 49, 1505–1511 (1991).
20.
Wilson, F. A. O'Scalaidhe, S. P. & Goldman-Rakic, P. S. Proc. natn. Acad. Sci. U.S.A. 91, 4009–4013 (1994).
- - CAS
  - Google Scholar
21.
Sawaguchi, T., Matsumura, M. & Kubota, K. J. Neurophysiol. 63, 1401–1412 (1990).
22.
Fuster, J. M. in The Prefrontal Cortex 2nd edn 51–82 (Raven, New York, 1989).
- - Google Scholar
23.
Goldman-Rakic, P. S. in Handbook of Physiology Vol. 5 (eds Mountcastle, V. B., Plum, F. & Geiger, S. R.) 373–417 (American Physiology Society, Bethesda, MD, 1987).
- - Google Scholar
24.
Malmberg, A., Jackson, D. M., Eriksson, A. & Mohell, N. Molec. Pharmac. 43, 749–754 (1993).
- - CAS
  - Google Scholar
25.
Dearry, A. et al. Nature 347, 72–76 (1990).
26.
Civelli, O., Bunzow, J. R. & Grandy, D. K. A. Rev. Pharmac. Tox. 33, 281–307 (1993).
- - CAS
  - Google Scholar
27.
Smiley, J. F., Levey, A. I., Ciliax, B. J. & Goldman-Rakic, P. S. Proc. natn. Acad. Sci. U.S.A. 91, 5720–5724 (1994).
- - CAS
  - Google Scholar
28.
Bergson, C. et al. Soc. Neurosci. Abstr. 20, 275 (1994).
- - Google Scholar
29.
Goldman-Rakic, P. S. et al. Proc. natn. Acad. Sci. U.S.A. 86, 9015–9019 (1989).
- - CAS
  - Google Scholar
30.
Goldman-Rakic, P. S. Prog. Brain. Res. 85, 325–335 (1990).
31.
Luciana, M., Depue, A. R., Arbisi, P. & Leon, L. J. cogn. Neurosci. 4, 58–68 (1992).
32.
Arnsten, A. F. T., Cai, J. X., Steere, J. C. & Goldman-Rakic, P. S. J. Neurosci. 15, 3429–3439 (1995).
33.
Bushnell, P. J. & Levin, E. D. Pharmac. Biochem. Behav. 45, 765–776 (1983).
- - Google Scholar
34.
Godbout, R., Mantz, J., Pirot, S., Glowinski, J. & Thierry, A. M. J. Pharmac. exp. Ther. 258, 728–738 (1991).
- - CAS
  - Google Scholar
35.
Berger, B., Gaspar, P. & Verney, C. Trends Neurosci. 14, 21–27 (1991).
36.
Van Eden, C. G. et al. Neuroscience 22, 849–862 (1987).
37.
Séguéla, P., Watkins, K. C. & Descarries, L. Brain Res. 442, 11–22 (1988).
38.
Thierry, A. M., Mantz, J., Milla, C. & Glowinski, J. Ann. N. Y. Acad. Sci. 537, 101–111 (1988).
39.
Calabresi, P. et al. Neuroscience 20, 757–771 (1987).
40.
Goldstein, L. E., Rasmusson, A. M., Bunney, B. S. & Roth, R. H. J. Neurosci. 14, 4937–4950 (1994).
41.
Shurtleff, D. et al. Pharmac. Biochem. Behav. 47, 935–941 (1994).
- - CAS
  - Google Scholar
42.
Bauer, R. H. & Fuster, J. M. Pharmac. Biochem. Behav. 8, 243–249 (1978).
- - CAS
  - Google Scholar
43.
Sabater, R., Saez, J. A. & Ferrer, J. M. Eur. J. Pharmac. 242, 205–208 (1993).
- - CAS
  - Google Scholar
44.
Millar, J. & Williams, G. V. J. comp. Neurol. 287, 119–133 (1989).
45.
Millar, J. & Williams, G. V. J. Neurosci. Meth. 25, 59–62 (1988).
- - CAS
  - Google Scholar

Download references

Author information

Affiliations

Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
- Graham V. Williams
- & Patricia S. Goldman-Rakic

Authors

Search for Graham V. Williams in:
- Nature Research journals •
- PubMed •
- Google Scholar
Search for Patricia S. Goldman-Rakic in:
- Nature Research journals •
- PubMed •
- Google Scholar

Rights and permissions

To obtain permission to re-use content from this article visit RightsLink.

About this article

Publication history

Received

06 April 1995

Accepted

26 June 1995

Published

17 August 1995

DOI

https://doi.org/10.1038/376572a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Subjects