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Requirement for LIml in head-organizer function

Nature volume 374, pages 425430 (30 March 1995) | Download Citation

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Abstract

Liml is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Liml during embryogenesis, a targeted deletion of the Liml gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Liml is thus an essential regulator of the vertebrate head organizer.

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References

  1. 1.

    & Wilhelm Roux Arch. Entw. Mech. Org. 100, 599–638 (1924).

  2. 2.

    J. exp. Biol. 10, 38–46 (1932).

  3. 3.

    Development 120, 613–620 (1994).

  4. 4.

    & Development 113, 1495–1505 (1991).

  5. 5.

    et al. Cell 69, 1097–1106 (1992).

  6. 6.

    , , & Cell 67, 1111–1120 (1991).

  7. 7.

    , , & Cell 74, 645–659 (1993).

  8. 8.

    & Genes Dev. 6, 599–608 (1992).

  9. 9.

    & Development 116, 81–93 (1992).

  10. 10.

    & Development 118, 47–59 (1993).

  11. 11.

    et al. Development 119, 1301–1315 (1993).

  12. 12.

    , & Genes Dev. 7, 355–366 (1993).

  13. 13.

    , , & Development 119, 991–1004 (1993).

  14. 14.

    , , & Genes Dev. 6, 356–366 (1992).

  15. 15.

    , & Nature 344, 876–879 (1990).

  16. 16.

    , , , & Nature 344, 879–882 (1990).

  17. 17.

    & Cell 54, 5–16 (1988).

  18. 18.

    , , & Development 120, 1525–1536 (1994).

  19. 19.

    , , & Nature 372, 677–679 (1994).

  20. 20.

    , , , & Devl Biol. 161, 168–178 (1994).

  21. 21.

    et al. Dev. Dynamics 199, 73–83 (1994).

  22. 22.

    , , , & Nature 358, 687–690 (1992).

  23. 23.

    , , & Development 120, 2979–2989 (1994).

  24. 24.

    & Genes Dev. 2, 1736–1744 (1988).

  25. 25.

    , , , & Nature 337, 461–464 (1989).

  26. 26.

    Development 113, 913–917 (1991).

  27. 27.

    et al. Cell 78, 575–588 (1994).

  28. 28.

    et al. Nature 361, 543–547 (1993).

  29. 29.

    et al. Development 120, 1919–1928 (1994).

  30. 30.

    The House Mouse: Atlas of Embryonic Development (Springer, New York, 1989).

  31. 31.

    , & Nature 343, 657–659 (1990).

  32. 32.

    et al. Development 116, 1123–1136 (1992).

  33. 33.

    Naturwissenschaften 15, 946–951 (1927).

  34. 34.

    Wilhelm Roux Arch. Entw. Mech. Org. 123, 389–517 (1931).

  35. 35.

    , & in Gastrulation: Movements, Patterns and Molecules (eds Keller, R., Clark, W. H. Jr & Griffin, F.) 57–77 (Plenum, New York, 1991).

  36. 36.

    in Postimplantation Development in the Mouse (eds Chadwick, D. J. & Marsh, J.) 55–58 (Wiley, Chichester, 1992).

  37. 37.

    J. Embryol, exp. Morph. 32, 1–33 (1974).

  38. 38.

    & Differentiation 117, 96–98 (1982).

  39. 39.

    & in Postimplantation Development in the Mouse (eds Chadwick, D. J. & Marsh J.) 27–49 (Wiley, Chichester, 1992).

  40. 40.

    Development 120, 3051–3062 (1994).

  41. 41.

    J. Neurobiol. 24, 1276–1304 (1993).

  42. 42.

    & Cell 78, 561–574 (1994).

  43. 43.

    in In Situ Hybridization (ed. Wilkinson, D. G.) 75–83 (IRL, Oxford, 1992).

  44. 44.

    & Development 118, 1255–1266 (1993).

  45. 45.

    , , & Cell 64, 694–702 (1991).

  46. 46.

    & Cell 62, 1073–1085 (1990).

  47. 47.

    , & Nature 336, 348–352 (1988).

  48. 48.

    et al. Analyt. Biochem. 201, 331–335 (1992).

  49. 49.

    in Teratocarcinomas and Embryonic Stem Cells (ed. Robertson, E. J.) 113–151 (IRL, Oxford, 1987).

  50. 50.

    , , & Development 11, 287–298 (1991).

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Affiliations

  1. Department of Molecular Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA

    • William Shawlot
    •  & Richard R. Behringer

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https://doi.org/10.1038/374425a0

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