Abstract
LITTLE is known about the way higher-order chromatin structure influences gene expression and chromosome topology in general. Genetic analysis in Drosophila has led to the discovery of two classes of genes, the regulators of homeotic genes and the modifiers of position-effect variegation, which seem to be good candidates for encoding some of the factors regulating chromatin functions1,2. The Trithorax-like gene we describe here is required for the normal expression of the homeotic genes and is a modifier of position-effect variegation. We found that Trithorax-like encodes the GAGA factor which is involved in the formation of an accessible chromatin structure at promoter sequences3. Our genetic analysis suggests that the chromatin modelling function of the GAGA factor is not restricted to promoter regions.
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References
Paro, R. Trends Genet. 6, 416–421 (1990).
Reuter, G. & Spierer, P. BioEssays 14, 605–612 (1992).
Tsukiyama, T., Becker, P. & Wu, C. Nature 367, 525–532 (1994).
Lewis, E. B. Nature 276, 565–570 (1978).
Ingham, P. W. Wilhelm Roux Arch. dev. Biol. 190, 365–369 (1981).
Shearn, A. Genetics 121, 517–525 (1989).
Celniker, S. E., Sharma, S., Keelan, D. J. & Lewis, E. B. EMBO J. 9, 4277–4286 (1990).
Dorn, R. et al. Genetics 133, 279–290 (1993).
Soeller, W. C., Euk Oh, C. & Kornberg, T. B. Molec. cell. Biol. 13, 7961–7970 (1993).
Biggin, M. & Tijian, R. Cell 53, 699–711 (1988).
Gilmour, D., Thomas, G. & Elgin, S. C. Science 245, 1487–1490 (1989).
Soeller, W. C., Poole, S. J. & Kornberg, T. Genes Dev. 2, 68–81 (1988).
Thummel, C. Genes Dev. 6, 2635–2645 (1989).
Read, D., Nishigaki, T. & Manley, J. L. Molec. cell. Biol. 10, 4334–4344 (1990).
Kerrigan, L. A., Croston, G. E., Lira, L. M. & Kadonaga, J. T. J. biol. Chem. 266, 574–582 (1991).
Harrison, S. H. & Travers, A. A. EMBO J. 9, 207–216 (1990).
Chi, H. C., Juminaga, D., Wang, S. Y. & Hui, C. F. Molec. cell. Biol. 10, 451–466 (1991).
Lee, J., Kraus, W., Wolfner, M. F. & Lis, J. Genes Dev. 6, 284–295 (1992).
Lu, Q., Wallrath, L. L., Granok, H. & Elgin, S. C. Molec. cell. Biol. 13, 2802–2814 (1993).
Croston, G. E., Kerrington, L. A., Lira, L. M., Marshak, D. R. & Kadonaga, J. T. Science 251, 643–649 (1991).
DiBello, P. R., Withers, D. A., Bayer, C. A., Fristrom, J. W. & Guild, G. M. Genetics 129, 385–397 (1991).
Godt, D., Couderc, J. L., Cramton, S. E. & Laski, F. A. Development 119, 799–812 (1993).
Xue, F. & Cooley, L. Cell 72, 681–693 (1993).
Dorn, R., Reuter, G. & Saumweber, H. Proc. natn. Acad. Sci. U.S.A. 90, 11376–13380 (1994).
Duncan, I. Genetics 102, 49–70 (1982).
Galloni, M., Gyurkovics, H., Schedl, P. & Karch, F. EMBO J. 12, 1087–1097 (1993).
Brown, N. & Kafatos, N. J. molec. Biol. 203, 425–437 (1988).
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Farkas, G., Gausz, J., Galloni, M. et al. The Trithorax-like gene encodes the Drosophila GAGA factor. Nature 371, 806–808 (1994). https://doi.org/10.1038/371806a0
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DOI: https://doi.org/10.1038/371806a0
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