Abstract
An intracellular compartment has been isolated to which MHC class II molecules are transported on their way to the plasma membrane. They arrive with an associated invariant chain which is then proteolytically processed while MHC class II molecules acquire antigenic peptide. These loaded class II molecules then leave the compartment devoid of invariant chain and bound for the plasma membrane. This compartment represents a new stage in the endocytic/ lysosomal pathway.
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References
Unanue, E. R. A. Rev. Immun. 2, 395–428 (1984).
Chicz, R. M. et al. J. exp. Med. 178, 27–47 (1993).
Townsend, A. et al. Nature 340, 443–448 (1989).
Cresswell, P., Blum, J. S., Kelner, D. N. & Marks, M. S. Crit. Rev. Immun. 7, 31–53 (1987).
Kvist, S., Wiman, K., Claesson, L., Peterson, P. A. & Dobberstein, B. Cell 29, 61–69 (1982).
Anderson, M. S. & Miller, J. Proc. natn. Acad. Sci. U.S.A. 89, 2282–2286 (1992).
Roche, P. A. & Cresswell, P. Nature 345, 615–618 (1990).
Teyton, L. et al. Nature 348, 39–44 (1990).
Lotteau, V. et al. Nature 348, 600–605 (1990).
Bakke, O. & Dobberstein, B. Cell 63, 707–716 (1990).
Blum, J. S. & Cresswell, P. Proc. natn. Acad. Sci. U.S.A. 85, 3975–3979 (1988).
Pieters, J., Horstmann, H., Bakke, O., Griffiths, G. & Lipp, J. J. Cell Biol. 115, 1213–1223 (1991).
Geuze, H. J., Slot, J. W., Strous, G. J. A. M., Lodish, H. F. & Schwartz, A. L. Cell 32, 277–287 (1983).
Hopkins, C. R., Gibson, A., Shipman, M. & Miller, K. Nature 346, 335–339 (1990).
Griffiths, G., Hoflack, B., Simons, K., Mellman, I. & Kornfeld, S. Cell 52, 329–337 (1988).
Schmid, S. L., Fuchs, R., Male, P. & Mellman, I. Cell 52, 73–83 (1988).
Gruenberg, J., Griffiths, G. & Howell, K. E. J. Cell Biol. 108, 1301–1316 (1989).
Kornfeld, S. & Mellman, I. A. Rev. Cell Biol. 5, 483–525 (1989).
Guagliardi, L. E. et al. Nature 343, 133–139 (1990).
Peters, P. J., Neefjes, J. J., Oorschot, V., Ploegh, H. L. & Geuze, H. J. Nature 349, 669–676 (1991).
Chen, Q. & Hersey, P. Int. J. Cancer 51, 218–224 (1992).
Germain, R. N. & Hendrix, L. R. Nature 353, 134–139 (1991).
Neefjes, J. J. & Ploegh, H. L. EMB0 J. 11, 411–416 (1992).
Marsh, M. et al. J. Cell Biol. 104, 875–886 (1987).
Hannig, K. & Heidrich, H. G. in Cell Separation Methods VI (eds Bloemendal, H.) 95–116 (Elsevier/North-Holland, Amsterdam, 1977).
Fukuda, M. J. biol. Chem. 266, 21327–21330 (1991).
Goda, Y. & Pfeffer, S. R. Cell 55, 309–329 (1988).
Teyton, L. & Peterson, P. A. Trends Cell Biol. 2, 52–56 (1992).
Lanzavecchia, L., Reid, P. A. & Watts, C. Nature 357, 249–252 (1992).
Pieters, J., Bakke, O. & Dobberstein, B. J. Cell Sci. 106, 831–864 (1993).
Neefjes, J. J., Stollorz, V., Peters, P. J., Geuze, H. J. & Ploegh, H. L. Cell 61, 171–183 (1990).
Hopkins, C. R. & Trowbridge, I. S. J. Cell Biol. 97, 508–521 (1983).
Sadegh-Nasseri, S. & Germain, R. N. Nature 353, 167–170 (1991).
Riberdy, J. M., Newcomb, J. R., Surman, M. J., Barbosa, J. A. & Cresswell, P. Nature 360, 474–477 (1992).
Germain, R. N. & Rinker, A. G. Jr, Nature 363, 725–728 (1993).
Harding, C. V. & Gueze, H. J., J. Immun. 151, 3988–3998 (1993).
Kelly, R. B. Nature 364, 487–488 (1993).
Feany, M. B. & Buckly, K. M. Nature 364, 537–540 (1993).
Koldovsky, O. & Palmieri, M. Biochem. J. 125, 697–701 (1971).
Brew, K., Shaper, J. L., Olsen, K. W., Trayer, I. P. & Hill, R. L. J. biol. Chem. 250, 1434–1444 (1975).
Bradford, M. Analyt. Biochem. 72, 248–254 (1976).
Gorvel, J.-P., Chavrier, P., Zerial, M. & Gruenberg, J. Cell 64, 915–925 (1991).
Tulp, A., Verwoerd, D. & Pieters, J. Electrophoresis 14, 1295–1301 (1993).
Hubbard, A. L. & Cohn, Z. A. J. Cell Biol. 64, 438–460 (1975).
Lampson, L. A. & Levy, R. J. Immun. 125, 293–299 (1980).
Shaw, S., Ziegler, A. & DeMars, R. Hum. Immun. 12, 191–211 (1985).
Parham, P., Barnstaple, C. J. & Bodmer, W. F. J. Immun. 123, 342–349 (1979).
Van de Rijn, M. et al. Cytogenet. Cell Genet. 36, 525–531 (1983).
O'Farrel, P. H. J. biol. Chem. 250, 4007–4021 (1975).
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Tulp, A., Verwoerd, D., Dobberstein, B. et al. Isolation and characterization of the intracellular MHC class II compartment. Nature 369, 120–126 (1994). https://doi.org/10.1038/369120a0
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DOI: https://doi.org/10.1038/369120a0
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