Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Product Review
  • Published:

A morphological biosensor for mammalian cells

An electrical biosensor is described that can continuously track morphological changes of adherent cells providing quantitative data from both sparse and confluent cultures. The method is capable of detecting vertical motion of cells of the order of 1 nm, much below the resolution of an optical microscope.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Giaever, I. & Keese, C. R. Proc. natn. Acad. Sci. U.S.A. 81, 3761–3764 (1984); IEEE Proc. biomed. Engng 33, 242–247 (1986); Physica D 39, 128–133 (1989).

    Article  ADS  CAS  Google Scholar 

  2. Kowolenko, M., Keese, C. R., Lawrence, D. A. & Giaever, I. J. Immunol. Methods 127, 71–77 (1990).

    Article  CAS  Google Scholar 

  3. Keese, C. R. & Giaever, I. IEEE Proc. biomed. Engng 12, 500–501 (1990).

    Google Scholar 

  4. Mitra, P., Keese, C. R. & Giaever, I. Biotechniques 11, 504–511 (1991).

    CAS  PubMed  Google Scholar 

  5. Giaever, I. & Keese, C. R. Proc. natn. Acad. Sci. U.S.A. 88, 7896–7900 (1991).

    Article  ADS  CAS  Google Scholar 

  6. Giaever, I. & Keese, C. R. Chemtech. 116–125 (Feb. 1992).

  7. Tiruppathi, C., Malik, A. B., Del Vecchio, P. J., Keese, C. R. & Giaever, I. Proc. natn. Acad. Sci. U.S.A. 89, 7919–7923 (1992).

    Article  ADS  CAS  Google Scholar 

  8. Lo, C. M., Keese, C. R. & Giaever, I. Exp. Cell Res. 204, 102–109 (1993).

    Article  CAS  Google Scholar 

  9. Ghosh, P. M., Keese, C. R. & Giaever, I. Biophys. J. 64, 1602–1609 (1993).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Giaever, I., Keese, C. A morphological biosensor for mammalian cells. Nature 366, 591–592 (1993). https://doi.org/10.1038/366591a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/366591a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing