Review Article | Published:

Social controls on cell survival and cell death

Nature volume 356, pages 397400 (02 April 1992) | Download Citation

Subjects

Abstract

Programmed cell death occurs in most animal tissues at some stage of their development, but the molecular mechanism by which it is executed is unknown. For some mammalian cells, programmed death seems to occur by default unless suppressed by signals from other cells. Such dependence on specific survival signals provides a simple way to eliminate misplaced cells, for regulating cell numbers and, perhaps, for selecting the fittest cells. But how general is this dependence on survival signals?

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    1. Glucksman, A. Biol. Rev. Camb. Philos. Soc. 26, 59-86 (1951). 2. Saunders, J. W. Science 154, 604-612 (1966). 3. Bowen, I. D. & Lockshin, R. A. (eds) Death in Biology and Pathology (Chapman & Hall, New York, 1981). 4. Kerr, J. F. R. J. Path. 105, 13-20 (1971). 5. Wyllie, A. H., Kerr, J. F. R., Macaskill, I. A. M. & Currie, A. R. J. Path. Ill, 85-94 (1973). 6. Benedetti, A, Jezequel, A. M. & Orlandi, F. J. Hepat. 7, 319-327 (1988). 7. Wyllie, A. H., Kerr, J. F. R. & Currie, A. R. Int Rev. Cytol. 68, 251-305 (1980). 8. Umansky, S. R. J. theor. Biol. 97, 591-602 (1982). 9. Ellis, R. E., Yuan, J. & Horvitz, H. R. A. Rev. Cell Biol. 7, 663-698 (1991). 10. Tomei, L. D. & Cope, F. 0. (eds) Apoptosis: the Molecular Basis of Cell Death (Cold Spring Harbor Laboratory Press, New York, 1991). 11. Hamburger, V. & Levi-Montalcini, R. J. exp. Zoo/. Ill, 457-501 (1949). 12. Cowan, W. M., Fawcett, J. W., O'Leary, D. D. M. & Stanfield, B. B. Science 225,1258-1265 (1984). 13. Purves, D. Body and Brain: A Trophic Theory of Neural Connections (Harvard University Press, Cambridge, MA, 1988). 14. Kerr, J. F. R., Harmon, B. & Searle, J. J. Cell Sci. 14, 571-585 (1974). 15. Lockshin, R. A. in Cell Death in Biology and Pathology (ed. Lockshin, R. A. & Bowen, I. D.) 79-122 (Chapman & Hall, New York, 1981). 16. Jost, A. Phil. Trans. R. Soc. B 259, 119-130 (1971). 17. Hammar, S. P. & Mottet. N. K. J. Cell Sci. 8, 229-236 (1971). 18. Cohen, J. J. Adv. Immun. 50, 55-85 (1991). 19. Golstein, P., Ojcius, D. M. & Young, J. D.-E. Immunol. Rev. 121, 29-65 (1991). 20. Sato, G. (ed.) Hormones and Cell Culture (Cold Spring Harbor Laboratory Press, New York, 1979). 21. Ham, R. G. in Tissue Growth Factors (ed. Baserga, R.) 13-38 (Springer, Heidelberg, 1981). 22. Baserga, R. The Biology of Cell Reproduction (Harvard University Press, Cambridge, MA, 1985). 23. Monpetit, M. L., Lawlap, K. R. & Tenniswood, M. Prostate 8, 25-36 (1986). 24. Wadewitz, A. G. & Lockshin, R. A. FEBS Lett. 241, 19-24 (1988). 25. Buttyan, R. et al. Molec. cell. Biol. 9, 3473-3481 (1989). 26. Schwartz, L. M., Kosz, L. & Kay, B. K. Proc. natn. Acad. Sci. U.S.A. 87, 6594-6598 (1990). 27. Tata, J. R. Devl Biol. 13, 77-94 (1966). 28. Duke, R. C. & Cohen, J. J. Lymphokine Res. 5, 289-299 (1986). 29. Martin, D. P. et al. J. Cell Biol. 106, 829-844 (1988). 30. Kerr, J. F. R., Wyllie, A. H. & Currie, A. R. Brit. J. Cancer 25, 239-257 (1972). 31. Searle, J., Kerr, J. F. R. & Bishop, C. J. Pathol. Annu. 17, 229-259 (1982). 32. Clarke, P. Anal Embryol. 181,195-213 (1990). 33. Lockshin, R. A. & Zakeri, Z. in Apoptosis: the Molecular Basis of Cell Death (eds Tomei, L. D. & Cope, F. 0.) 47-60 (Cold Spring Harbor Laboratory Press, New York, 1991). 34. Williams, J. R., Little, J. B. & Shipley, W. U. Nature 252, 754-755 (1974). 35. Wyllie. A. H. Nature 284, 555-556 (1980). 36. Ellis. R. E. & Horvitz. H. R. Cell 44, 817-829 (1986). 37. Yuan, J. & Horvitz, H. R. Devl Biol. 138, 33-41 (1990). 38. Hengartner, M. 0., Ellis, R. E. & Horvitz, H. R. Nature (in the press). 39. Vaux, D. L, Cory, S. & Adams, J. M. Nature 335, 440-442 (1988). 40. Nunez, G. et al. J. Immun. 144, 3602-3610 (1990). 41. Strasser, A, Harris, A. W. & Cory, S. Cell 67, 889-899 (1991). 42. Liu. Y.-J. et al. Eur. J. Immun. 21, 1905-1910 (1991). 43. Hockenbery, D. M., Nunez, G., Milliman, C., Schreiber, R. D. & Korsmeyer, S. J. Nature 348,334-336 (1990). 44. Tata, J. R. Soc. exp. Biol. Symp. 25, 161-181 (1971). 45. Wyllie, A. H., Morris, R. G., Smith, A. L. & Dunlop, D. J. Path. 142, 67-77 (1984). 46. Trauth, B. et al. Science 245, 301-305 (1989). 47. Itoh, N. et al. Cell 66, 233-243 (1991). 48. Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A. & Nagata, S. Nature (in the press). 49. Barde, Y.-A. Neuron 2, 1525-1534 (1989). 50. Oppenheim, R. W. A. Rev. Neurosci. 14, 453-501 (1991). 51. Kerr, J. F. R. & Searle, J. Virchows Arch. Zellpathol. 13, 87-92 (1973). 52. Krypaniou, N. & Issacs, J. T. Endocrinology 122, 552-562 (1988). 53. Metcalf, D. Nature 339, 27-30 (1989). 54. Williams, G. T., Smith, C. A., Spooner, E., Dexter, T. M. & Taylor, D. R. Nature 343, 76-79 (1990). 55. Koury, M. J. & Bondurant, M. C. Science 248, 378-380 (1990). 56. Araki, S., Shimada, Y., Kaji, K. & Hyashi, H. Biochem. biophys. Res. Commun. 168, 1194-1200 (1990). 57. Biggers, J. D., Whitten, W. K. & Whittingham, D. G. in Methods in Mammalian Embryology (ed. Daniel, J. C.) 86-116 (Freeman, San Francisco, 1971). 58. Tschan, T. et al. J. Cell Biol. Ill, 257-260 (1990). 59. Barres, B. et al. Cell (in the press). 60. Campenot, R. B. Devl Biol. 93, 13-21 (1982). 61. Mintz, B. & Russell, E. S. J. exp. Zoo/. 134, 207-237 (1957). 62. Byskov, A. G. in Reproduction in Mammals: I. Germ Cells and Fertilization (eds Austin, C. R. & Short, R. V.) 1-16 (Cambridge University Press, UK, 1982). 63. Godin, I. et al. Nature 352, 807-809 (1991). 64. Silvers, W. K. in The Coat Color of Mice: A Model for Mammalian Gene Action and Interaction (ed. Silvers, W. K.) 242-267 (Springer, New York, 1979). 65. Besmer, P. Curr. Opin. Cell Biol. 3, 939-946 (1991). 66. Matsui, Y., Zsebo, K. M. & Hogan, B. L. M. Nature 347, 667-669 (1990). 67. Keshet, E. et al. EMBO J. 10, 2135-2435 (1991). 68. Orr-Urtreger, A. et al. Development 109, 911-923 (1990). 69. Dolci, S. et al. Nature 352, 809-811 (1991). 70. Flanegan, J. G., Chan, D. C. & Leder, P. Cell 64, 1025-1035 (1991). 71. Hockenbery, D. M., Nunez, G., Milliman, C., Schreiber, R. D. & Korsmeyer, S. J. Nature 348,334-336 (1990). 72. Korsching, S. & Thoenen, H. Proc. natn. Acad. Sci. U.S.A. 80, 3513-3516 (1983). 73. Levi-Montalcini, R. EMBO J. 6, 1145-1154 (1987). 74. Bursch, W., Taper, H. S., Lauer, B. & Schulte-Hermann, R. Virchows Arch. Zellpathol. 50,153-166 (1985). 75. Columbano, A. et al. Lab. Invest. 52, 670-675 (1985). 76. Gates, P. S., Morgan, R. G. H. & Light, A. M. Amer. J. Physiol. 250, G9-14 (1986). 77. Ledda-Columbano,G. M., Columbano, A., Coni, P., Faa,G. & Pani, P. Am. J. Path. 135,657-662 (1989). 78. Aisenman, Y. & deVellis, J. Brain Res. 406, 32-42 (1987). 79. Svrzic, D. & Schubert, D. Biochem. biophys. Res. Commun. 172, 54-60 (1990). 80. Drago, J., Murphy, M., Carroll, S. M., Harvey, R. P. & Bartlett, P. G. Proc. natn. Acad. Sci. U.S.A. 88, 2199-2203 (1991). 81. Bowen-Pope, D. F. & Ross, R. Meth. Enzym. 109, 69-100 (1985). 82. Alberts, B. et al. Molecular Biology of the Cell 748 (Garland, New York, 1989). 83. Nowell, P. Science 194, 23-28 (1976).

Download references

Author information

Affiliations

  1. Department of Biology, Medawar Building, University College London, Gower Street, London WC1E 6BT, UK.

    • Martin C. Raff

Authors

  1. Search for Martin C. Raff in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/356397a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.