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The end of the beginning for pluripotent stem cells

Nature volume 414, pages 92–97 (2001)Cite this article

Abstract

Pluripotent stem cells can be expanded seemingly indefinitely in culture, maintain a normal karyotype and have the potential to generate any cell type in the body. As such they represent an incredible resource for the repair of diseased or damaged tissues in our bodies. These cells also promise to open a new window into the embryonic development of our species.

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Figure 1: Origin of human pluripotent stem cells.
Figure 2: Differentiation of pluripotent stem cells into differentiated derivatives.
Figure 3: Isolation and separation of differentiated cells from pluripotent stem cells.

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Acknowledgements

We apologize to the colleagues whose work was not cited because of space constraints. We are indebted to L. F. Lock for critical comments on the manuscript and with L. Cheng, D. Panchision, H. Scholer, M. Bartolomei, L. Iacovitti and J. McLaughlin for helpful discussions. We thank M. Linkinhoker for help with the figures.

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  1. Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, 19107, Pennsylvania, USA

    Peter J. Donovan

  2. The Institute of Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA

    John Gearhart

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Donovan, P., Gearhart, J. The end of the beginning for pluripotent stem cells. Nature 414, 92–97 (2001). https://doi.org/10.1038/35102154

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