The traditional view is that, when a cellular protein becomes linked to a modifying group known as ubiquitin, it's curtains for that protein. But non-destructive functions for ubiquitin are now emerging.
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Finley, D. An alternative to destruction. Nature 412, 283–285 (2001). https://doi.org/10.1038/35085671
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DOI: https://doi.org/10.1038/35085671
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