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Bone-marrow transplantation

Failure to correct murine muscular dystrophy

Nature volume 411, pages 1014–1015 (2001)Cite this article

Abstract

Bone-marrow cells have the potential to differentiate into other cell types such as muscle fibres, and can be transplanted into acutely1 or chronically2 damaged muscle as a way of delivering normal dystrophin (the protein that is defective or missing in Duchenne's muscular dystrophy) to the skeletal and heart muscle of mdx mice2,3, an animal model for this disease. But the corrective potential of this approach has been hard to estimate against the high background of muscle fibres that spontaneously revert to synthesizing dystrophin, a feature of the original mdx mutation4. Here we test the long-term efficacy of bone-marrow transplantation in a different mdx mutant which is free of this problem and find that it has no impact on murine muscular dystrophy.

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Figure 1: Expression of dystrophin in mdx mice 6 months after transplantation with bone-marrow cells from co-isogenic, normal donors.

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References

  1. Ferrari, G. et al. Science 279, 1528–1530 (1998).

    Article  ADS  CAS  Google Scholar 

  2. Gussoni, E. et al. Nature 401, 390–394 (1999).

    ADS  CAS  Google Scholar 

  3. Bittner, R. E. et al. Anat. Embryol. 199, 391–396 (1999).

    Article  CAS  Google Scholar 

  4. Danko, I. et al. Pediatr. Res. 32, 128–131 (1992).

    Article  CAS  Google Scholar 

  5. Emery, A. E. H. Duchenne Muscular Dystrophy 2nd edn (Oxford Univ. Press, Oxford, 1993).

    Google Scholar 

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Author information

Authors and Affiliations

  1. H. San Raffaele-Telethon Institute for Gene Therapy, Via Olgettina 58, Milano, 20132, Italy

    Giuliana Ferrari & Fulvio Mavilio

  2. GenEra SpA, Via Olgettina 58, Milano, 20132, Italy

    Anna Stornaiuolo

  3. Department of Biomedical Sciences, University of Modena School of Medicine, Modena, 41100, Italy

    Fulvio Mavilio

Authors
  1. Giuliana Ferrari
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  2. Anna Stornaiuolo
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  3. Fulvio Mavilio
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Correspondence to Fulvio Mavilio.

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Ferrari, G., Stornaiuolo, A. & Mavilio, F. Failure to correct murine muscular dystrophy. Nature 411, 1014–1015 (2001). https://doi.org/10.1038/35082631

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