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Cancer

Telomerase meets its mismatch

Cells cannot survive without telomeres, the sequences that cap the ends of chromosomes, so cancer cells activate a telomere-generating enzyme. Studies of yeast now hint that they have a second way to make telomeres.

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Figure 1: Mismatch repair in cancer.

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Kucherlapati, R., DePinho, R. Telomerase meets its mismatch. Nature 411, 647–648 (2001). https://doi.org/10.1038/35079715

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