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Memory

Why is the cortex a slow learner?

Mice that have only half the normal amount of a synaptic protein called α-CaMKII learn normally, but remember poorly. The result sheds light on the mysterious mechanisms of memory consolidation.

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References

  1. Frankland, P. W., O' Brien, C., Ohno, M., Kirkwood, A. & Silva, A. J. Nature 411, 309–313 (2001).

    Article  ADS  CAS  Google Scholar 

  2. Martin, S. J. et al. Annu. Rev. Neurosci. 23, 649–711 (2000).

    Article  CAS  Google Scholar 

  3. McGaugh, J. L. Science 153, 1351–1358 (1966).

    Article  ADS  CAS  Google Scholar 

  4. Squire, L. R. Psychol. Rev. 99, 195–231 (1992).

    Article  CAS  Google Scholar 

  5. Buzsáki, G. Neuroscience 31, 551–570 (1989).

    Article  Google Scholar 

  6. Eichenbaum, H. B. & Nadel, L. (eds) Hippocampus 11, 1–60 (2001).

    Article  Google Scholar 

  7. Skaggs, W. & McNaughton B. Science 274, 1870–1873 (1996).

    Article  ADS  Google Scholar 

  8. Louie, K. & Wilson, M. Neuron 29, 145–156 (2001).

    Article  CAS  Google Scholar 

  9. Kennedy, M. B. Nature 335, 770–772 (1988).

    Article  ADS  CAS  Google Scholar 

  10. Lisman, J. Trends Neurosci. 17, 406–412 (1994).

    Article  CAS  Google Scholar 

  11. Hebb, D. O. The Organization of Behaviour (Wiley, New York, 1949).

    Google Scholar 

  12. Rolls, E. T. & Treves, A. Neural Networks and Brain Function (Oxford Univ. Press, 1998).

    Google Scholar 

  13. Darian-Smith, C. & Gilbert, C. Nature 368, 737–740 (1994).

    Article  ADS  CAS  Google Scholar 

  14. Klintsova, A. & Greenough, W. Curr. Opin. Neurobiol. 9, 203–208 (1999).

    Article  CAS  Google Scholar 

  15. Bailey, C. et al. Nature Rev. Neurosci. 1, 11–20 (2000).

    Article  CAS  Google Scholar 

  16. Florence, S. L. et al. Science 282, 1062–1063 (1998).

    Article  Google Scholar 

  17. Anagnosteras, S. G. et al. J. Neurosci. 19, 1106–1114 (1999).

    Article  Google Scholar 

  18. Nadel, L. & Moscovitch, M. Curr. Opin. Neurobiol. 7, 217–227 (1997).

    Article  CAS  Google Scholar 

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Lisman , J., Morris , R. Why is the cortex a slow learner?. Nature 411, 248–249 (2001). https://doi.org/10.1038/35077185

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