Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DNA replication

SOS polymerases

The standard DNA-replicating machinery cannot copy damaged DNA, so SOS enzymes come to the rescue. It now seems, at least in some bacteria, that different enzymes are required for different types of damage.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Translesional polymerases continue to replicate DNA even when it contains errors that make other DNA polymerases stall.

References

  1. Friedberg, E. C., Feaver, W. J. & Gerlach, V. L. Proc. Natl Acad. Sci. USA 97, 5681–5683 (2000).

    Article  ADS  CAS  Google Scholar 

  2. Napolitano, R., Janel-Bintz, R., Wagner, J. & Fuchs, R. P. P. EMBO J. 19, 6259–6265 (2000).

    Article  CAS  Google Scholar 

  3. Wagner, J., Fujii, S., Gruz, P., Nohmi, T. & Fuchs, R. P. P. EMBO Rep. 1, 484 –488 (2000).

    Article  CAS  Google Scholar 

  4. Tang, M. et al. Proc. Natl Acad. Sci. USA 96, 8919– 8924 (1999).

    Article  ADS  CAS  Google Scholar 

  5. Reuven, N. B., Arad, G., Maor-Shoshani, A. & Livneh, Z. J. Biol. Chem. 274, 31763–31766 (1999).

    Article  CAS  Google Scholar 

  6. Friedberg, E. C., Walker, G. C. & Siede, W. DNA Repair and Mutagenesis (ASM, Washington DC, 1995).

  7. Brotcorne-Lannoye, A. & Maenhaut-Michel, G. Proc. Natl Acad. Sci. USA 83, 3904–3908 (1986).

    Article  ADS  CAS  Google Scholar 

  8. Kim, S.-R et al. Proc. Natl Acad. Sci. USA 94, 13792– 13797 (1997).

    Article  ADS  CAS  Google Scholar 

  9. Wagner, J. et al. Mol. Cell 4, 281–287 (1999).

    Article  CAS  Google Scholar 

  10. Tang, M. et al. Nature 404, 1014–1018 (2000).

    Article  ADS  CAS  Google Scholar 

  11. Radman, M. in Molecular and Environmental Aspects of Mutagenesis (eds Sherman, F., Miller, M., Lawrence, C. & Tabor, W. H.) 128–142 (Thomas, Springfield, IL, 1974).

    Google Scholar 

  12. Masutani, C. et al. EMBO J. 18, 3491–3501 (1999).

    Article  CAS  Google Scholar 

  13. Masutani, C. et al. Nature 399, 700–704 (1999).

    Article  ADS  CAS  Google Scholar 

  14. Johnson, R. E., Kondratick, C. M., Prakash, S. & Prakash, L. Science 285, 263–265 ( 1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fumio Hanaoka.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hanaoka, F. SOS polymerases. Nature 409, 33–34 (2001). https://doi.org/10.1038/35051208

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35051208

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing