Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Natural Selection

Evolving evolvability

Nature volume 407, pages 457–458 (2000)Cite this article

In yeast, a modified protein known as a prion generates variation in growth rate across diverse environments. Is this an example of an agent that has evolved in order to promote its possessor's adaptability?

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Protein production and the effects of the Sup35 protein and its modified form, the [PSI+] prion, in yeast.

References

  1. Johnson, T. Genetics 151, 1621–1631 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Barton, N. H. & Charlesworth, B. Science 281, 1986–1990 (1998).

    Article  CAS  Google Scholar 

  3. True, H. L. & Lindquist, S. L. Nature 407, 477–483 (2000).

    Article  ADS  CAS  Google Scholar 

  4. Wagner, A. Nature Genet. 24, 355–361 (2000).

    Article  CAS  Google Scholar 

  5. Taddei, F. et al. Nature 387, 700–703 (1997).

    Article  ADS  CAS  Google Scholar 

  6. Waddington, C. H. Nature 150, 563–565 ( 1942).

    Article  ADS  Google Scholar 

  7. McLaren, A. Trends Genet. 15, 169–171 (1999).

    Article  CAS  Google Scholar 

  8. Gibson, G. & Wagner, G. Bioessays 22, 372–380 (2000).

    Article  CAS  Google Scholar 

  9. Rutherford, S. L. & Lindquist, S. Nature 396, 336–342 (1998).

    Article  ADS  CAS  Google Scholar 

  10. Coyne, J. A., Barton, N. H. & Turelli, M. Evolution 51, 643– 671 (1997).

    Article  Google Scholar 

  11. Metzgar, D. & Wills, C. Cell 101, 581 –584 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK

    Linda Partridge

  2. Institute for Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK

    Nicholas H. Barton

Authors
  1. Linda Partridge
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nicholas H. Barton
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Partridge, L., Barton, N. Evolving evolvability. Nature 407, 457–458 (2000). https://doi.org/10.1038/35035173

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35035173

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing