The technique known as protein signature analysis, developments of which were discussed by Satish K. Nair and Stephen K. Burley in the article “Functional genomics: Recognizing DNA in the library” (Nature 404, 715–718 (2000).), was originally described in a paper by T.W. Muir, P.E. Dawson, M.C. Fitzgerald and S.B. Kent in Chemistry and Biology (3, 817–825; 1996).