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Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin

Nature volume 349, pages 691–694 (1991)Cite this article

Abstract

A CENTRAL feature of host defence is the ability of leukocytes to enter tissues in response to immune or inflammatory stimuli. The leukocyte adhesion molecule-1 (LAM-1) regulates the migration of human leukocytes by mediating the binding both of lymphocytes to high endothelial venules of peripheral lymph nodes and of neutrophils to endothelium at inflammatory sites1–10. As lymphocytes and neutrophils express the same LAM-1 protein11,12, it is not clear how lineage-specific differences in leukocyte migration are controlled. We now report that the affinity of LAM-1 for a carbohydrate-based ligand, PPME13–16, is dramatically increased following lymphocyte and neutrophil activation by lineage-specific stimuli. In addition, activation of lymphocytes by physiological stimuli enhanced LAM-1-dependent binding to high endothelial venules. Thus, transient changes in LAM-1 affinity after leukocyte stimulation probably directly influence leukocyte migration.

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Authors and Affiliations

  1. Division of Tumor Immunology, Dana-Farber Cancer Institute,

    Olivier Spertini, Geoffrey S. Kansas, J. Michael Munro, James D. Griffin & Thomas F. Tedder

  2. Departments of Pathology and Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Olivier Spertini, Geoffrey S. Kansas, J. Michael Munro, James D. Griffin & Thomas F. Tedder

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  1. Olivier Spertini
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  4. James D. Griffin
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  5. Thomas F. Tedder
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Spertini, O., Kansas, G., Munro, J. et al. Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. Nature 349, 691–694 (1991). https://doi.org/10.1038/349691a0

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