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A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein β-adaptin

Nature volume 349, pages 215–220 (1991)Cite this article

Abstract

Four high-molecular-weight proteins form the main subunits of the coat of Golgi-derived (non-clathrin) coated vesicles. One of these coat proteins, β-COP, is identical to a Golgi-associated protein of relative mass 110,000 (110K) that shares homology with the adaptin proteins of clathrin-coated vesicles. This connection, and the comparable molecular weights of the coat proteins of Golgi-derived and clathrin-coated vesicles, indicates that they may be structurally related. The identification of β-COP as the 110K protein explains the blocking of secretion by the drug brefeldin A.

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Author notes

  1. James E. Rothman: Address from 1 June 1991

Authors and Affiliations

  1. Department of Biochemistry, Stanford University, Stanford, California, 94305, USA

    Tito Serafini

  2. Department of Molecular Biology, Princeton University, Princeton, New Jersey, 08544, USA

    Tito Serafini & James E. Rothman

  3. Institut für Biochemie I, Universität Heidelberg, D-6900, Heidelberg, Germany

    Gudrun Stenbeck, Andreas Brecht & Felix T. Wieland

  4. Genzentrum, Max Planck Institut für Biochemie, D-8033, Martinsried bei München, Germany

    Friedrich Lottspeich

  5. Département de Morphologic, Universite dé Genève, 1211, Genève, 4, Switzerland

    Lelio Orel

  6. Program in Molecular Cell Biology, Rockefeller Research Laboratory, Sloan-Kettering Institute, 1275 York Avenue, New York, New York, 10021, USA

    James E. Rothman

Authors
  1. Tito Serafini
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  2. Gudrun Stenbeck
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  7. Felix T. Wieland
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Serafini, T., Stenbeck, G., Brecht, A. et al. A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein β-adaptin. Nature 349, 215–220 (1991). https://doi.org/10.1038/349215a0

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