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A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

Nature volume 348, pages 699–704 (1990)Cite this article

Abstract

A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.

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Author notes

  1. P. Chambon: To whom correspondence should be addressed.

Authors and Affiliations

  1. Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de I'lNSERM, Institut de Chimie Biologique, Faculté de Médecine, 11 Rue Humann, 67085, Strasbourg Cédex, France

    P. Basset, C. Wolf, I. Stoll, P. Hutin, J. M. Limacher, O. L. Podhajcer, M. C. Rio & P. Chambon

  2. Service d'Anatomie Pathologique Générate, Centre Hospitalier Universitaire, 67098, Strasbourg Cédex, France

    J. P. Bellocq & M. P. Chenard

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  1. P. Basset
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Basset, P., Bellocq, J., Wolf, C. et al. A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature 348, 699–704 (1990). https://doi.org/10.1038/348699a0

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