Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins

Nature volume 348, pages 610–616 (1990)Cite this article

Abstract

The mitochondrial import receptors MOM19 and MOM72 form a complex with two other proteins of the mitochondrial outer membrane, MOM38 and MOM22. This receptor complex is involved in recognition, membrane insertion and translocation of precursor proteins with MOM38 constituting (at least part of) the general insertion site GIP.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Wickner, W. T. & Lodish, H. F. Science 230, 400–407 (1985).

    Article  ADS  CAS  Google Scholar 

  2. Hartl, F.-U. & Neupert, W. Science 247, 930–938 (1990).

    Article  ADS  CAS  Google Scholar 

  3. Pfanner, N. & Neupert W. A. Rev. Biochem. 59, 331–353 (1990).

    Article  CAS  Google Scholar 

  4. Horwich, A. Curr. Opinion Cell Biol. 2, 625–633 (1990).

    Article  CAS  Google Scholar 

  5. Deshaies, R. J., Koch, B. D., Wener-Washburne, M., Craig, E. A. & Schekman, R. Nature 332, 800–805 (1988).

    Article  ADS  CAS  Google Scholar 

  6. Murakami, H., Pain, D. & Blobel, G. J. Cell Biol. 107, 2051–2057 (1988).

    Article  CAS  Google Scholar 

  7. Randall, S. K. & Shore, G. C. FEBS Lett. 250, 561–564 (1989).

    Article  CAS  Google Scholar 

  8. Pfanner, N. et al. J. biol. Chem. 265, 16324–16329 (1990).

    CAS  PubMed  Google Scholar 

  9. Söllner, T., Griffiths, G., Pfaller, R., Pfanner, N. & Neupert, W. Cell 59, 1061–1070 (1989).

    Article  Google Scholar 

  10. Steger, H. F. et al. J. Cell Biol. 111 (in the press).

  11. Söllner, T., Pfaller, R., Griffiths, G., Pfanner, N. & Neupert, W. Cell 62, 107–115 (1990).

    Article  Google Scholar 

  12. Vestweber, D., Brunner, J., Baker, A. & Schatz, G. Nature 341, 205–209 (1989).

    Article  ADS  CAS  Google Scholar 

  13. Kang, P.-J. et al. Nature 348, 137–143 (1990).

    Article  ADS  CAS  Google Scholar 

  14. Cheng, M. Y. et al. Nature 337, 620–625 (1989).

    Article  ADS  CAS  Google Scholar 

  15. Ostermann, J., Horwich, A. L., Neupert, W. & Hatl, F.-U. Nature 341, 125–130 (1989).

    Article  ADS  CAS  Google Scholar 

  16. Hawlitschek, G. et al. Cell 53, 795–806 (1988).

    Article  CAS  Google Scholar 

  17. Yang, M., Jensen, R. E., Yaffe, M. P., Oppliger, W. & Schatz, G. EMBO J. 7, 3857–3862 (1988).

    Article  CAS  Google Scholar 

  18. Pfaller, R., Steger, H. F., Rassow, J., Pfanner, N. & Neupert, W. J. Cell Biol. 107, 2483–2490 (1988).

    Article  CAS  Google Scholar 

  19. Pfanner, N., Hartl, F.-U. & Neupert, W. Eur. J. Biochem. 175, 205–212 (1988).

    Article  CAS  Google Scholar 

  20. Vestweber, D. & Schatz, G. J. Cell Biol. 107, 2037–2043 (1988).

    Article  CAS  Google Scholar 

  21. Rassow, J. et al. J. Cell Biol. 109, 1421–1428 (1989).

    Article  CAS  Google Scholar 

  22. Zwinzinski, C., Schleyer, M. & Neupert, W. J. biol. Chem. 259, 7850–7856 (1984).

    Google Scholar 

  23. Pfanner, N. & Neupert, W. J. biol. Chem. 262, 7528–7536 (1987).

    CAS  Google Scholar 

  24. Pfanner, N., Tropschug, M. & Neupert, W. Cell 49, 815–823 (1987).

    Article  CAS  Google Scholar 

  25. Schleyer, M. & Neupert, W. Cell 43, 339–350 (1985).

    Article  CAS  Google Scholar 

  26. Chen, W.-J. & Douglas, M.G. Cell 49, 651–658 (1987).

    Article  CAS  Google Scholar 

  27. Schwaiger, M., Herzog, V. & Neupert, W. J. Cell. Biol. 105, 235–246 (1987).

    Article  CAS  Google Scholar 

  28. Klingenberg, M. Ann. N. Y. Acad. Sci. 456, 279–288 (1985).

    Article  ADS  CAS  Google Scholar 

  29. Schneider, H., Arretz, M., Wachter, E. & Neupert, W. J. biol. Chem. 265, 9881–9887 (1990).

    CAS  Google Scholar 

  30. Chin, D. T., Goff, S. A., Webster, T., Smith, T. & Goldberg, A. L. J. biol. Chem. 263, 11718–11728 (1988).

    CAS  PubMed  Google Scholar 

  31. von Heijne, G. EMBO J. 5, 1335–1342 (1986).

    Article  CAS  Google Scholar 

  32. Roise, D. & Schatz, G. J. biol. Chem. 263, 4509–4511 (1988).

    CAS  Google Scholar 

  33. Runswick, M. J., Powell, S. J., Nyren, P. & Walker, J. E. EMBO J. 6, 1367–1373 (1987).

    Article  CAS  Google Scholar 

  34. Phelps, A., Schobert, C. T. & Wohlrab, H. Biochemistry (in the press).

  35. Nies, D. H., Nies, A., Chu, L. & Silver, S. Proc. natn. Acad. Sci. U.S.A. 86, 7351–7355 (1989).

    Article  ADS  CAS  Google Scholar 

  36. Pfaller, R. & Neupert, W. EMBO J. 6, 2635–2642 (1987).

    Article  CAS  Google Scholar 

  37. Ohba, M. & Schatz, G. EMBO J. 6, 2109–2115 (1987).

    Article  CAS  Google Scholar 

  38. Laemmli, U. K. Nature 121, 680–685 (1970).

    Article  ADS  Google Scholar 

  39. Pfanner, N., Müller, H. K., Harmey, M. A. & Neupert, W. EMBO J. 6, 3449–3454 (1987).

    Article  CAS  Google Scholar 

  40. Pfanner, N. & Neupert, W. EMBO J. 4, 2819–2825 (1985).

    Article  CAS  Google Scholar 

  41. Hartl, F.-U., Schmidt, B., Wachter, E., Weiss, H. & Neupert, W. Cell 47, 939–951 (1986).

    Article  CAS  Google Scholar 

  42. Griffiths, G., Simons, K., Warren, G. & Tokuyasu, K. T. Meth. Enzym. 96, 466–485 (1983).

    Article  CAS  Google Scholar 

  43. Griffiths, G., McDowall, A., Back, R. & Dubochet, J. J. Ultrastruct. Res. 89, 65–78 (1984).

    Article  CAS  Google Scholar 

  44. Melton, D. A. et al. Nucleic Acids Res. 12, 7035–7056 (1984).

    Article  CAS  Google Scholar 

  45. Hartl, F.-U., Ostermann, J., Guiard, B. & Neupert, W. Cell 51, 1027–1037 (1987).

    Article  CAS  Google Scholar 

  46. Baker, K. P., Schaniel, A., Vestweber, D. & Schatz, G. Nature 348, 605–609 (1990).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Rupert Pfaller

    Present address: Department of Biology, University of California San Diego, La Jolla, California, 92093, USA

  2. Gareth Griffiths and Heinz Horstmann: European Molecular Biology Institute, W-6900 Heidelberg, Germany

Authors and Affiliations

  1. Institut für Physiologische Chemie, Universität München, Goethestrasse 33, W-8000, München, 2, Germany

    Michael Kiebler, Rupert Pfaller, Thomas Söllner, Gareth Griffiths, Heinz Horstmann, Nikolaus Pfanner & Walter Neupert

Authors
  1. Michael Kiebler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rupert Pfaller
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Thomas Söllner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gareth Griffiths
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Heinz Horstmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nikolaus Pfanner
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Walter Neupert
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kiebler, M., Pfaller, R., Söllner, T. et al. Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins. Nature 348, 610–616 (1990). https://doi.org/10.1038/348610a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/348610a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing