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Arabidopsis thaliana contains two genes for TFIID

Nature volume 346, pages 390–394 (1990)Cite this article

Abstract

THE general transcription initiation factor TFIID plays a primary part in the activation of eukaryotic genes transcribed by RNA polymerase II. Binding of TFIID to the TATA box initiates the assembly of other general transcription factors as well as RNA polymerase II at the promoter resulting in a preinitiation complex capable of accurate transcription initiation in vitro1–3. Human TFIID has been shown to interact with various regulatory factors4–8. The observation that stimulation of transcription by different trans-acting factors is mediated through distinct TATA elements led to the suggestion that different types of TFIID may exist in yeast9–11, humans12–15 and plants16. Here we report the cloning and characterization of two distinct TFIID complementary DNA clones from Arabidopsis thaliana. Furthermore, we have found that TFIID from Arabidopsis and other organisms shows homology to helix-loop-helix proteins.

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Author notes

  1. Nam-Hai Chua: To whom correspondence should be addressed

Authors and Affiliations

  1. Laboratory of Plant Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York, 10021-6399, USA

    Alexander Gasch & Nam-Hai Chua

  2. Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York, 10021-6399, USA

    Alexander Hoffmann, Masami Horikoshi & Robert G. Roeder

Authors
  1. Alexander Gasch
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  2. Alexander Hoffmann
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  3. Masami Horikoshi
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  4. Robert G. Roeder
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  5. Nam-Hai Chua
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Gasch, A., Hoffmann, A., Horikoshi, M. et al. Arabidopsis thaliana contains two genes for TFIID. Nature 346, 390–394 (1990). https://doi.org/10.1038/346390a0

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