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Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

Nature volume 342, pages 767–772 (1989)Cite this article

Abstract

The homoeobox-containing genes of the Hox-5 complex are expressed in different but overlapping domains in limbs during murine development. The more 5′ the position of these genes in the complex, the later and more distal is their expression. Antero-posterior differences are also observed. A model is proposed that accounts for the establishment of these expression domains in relation to the existence of a morphogen released by the zone of polarizing activity. Comparison of these observations with the expression patterns of the genes of Hox complexes in the early embryo suggests that similar molecular mechanisms are involved in the positional signalling along the axes of both the embryonic trunk and the fetal limbs.

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Author notes

  1. Pascal Dollé: LGME du CNRS, Unité INSERM 184, Faculté de Médecine, 11 rue Humann, 67085 Strasbourg Cedex, France

  2. Denis Duboule: To whom correspondence should be addressed.

Authors and Affiliations

  1. European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10.2209, 6900, Heidelberg, 1, FRG

    Pascal Dollé, Juan-Carlos Izpisúa-Belmonte, Hildegard Falkenstein, Armand Renucci & Denis Duboule

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  1. Pascal Dollé
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  2. Juan-Carlos Izpisúa-Belmonte
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  3. Hildegard Falkenstein
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  4. Armand Renucci
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  5. Denis Duboule
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Dollé, P., Izpisúa-Belmonte, JC., Falkenstein, H. et al. Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation. Nature 342, 767–772 (1989). https://doi.org/10.1038/342767a0

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