Abstract
In the transition state for unfolding of barnase, the hydrophobic core between the major α-helix and β-sheet is somewhat weakened, the C terminus of the major helix is largely intact but its N terminus is exposed and a major loop has been invaded by solvent.
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Matouschek, A., Kellis, J., Serrano, L. et al. Mapping the transition state and pathway of protein folding by protein engineering. Nature 340, 122–126 (1989). https://doi.org/10.1038/340122a0
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DOI: https://doi.org/10.1038/340122a0
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