Abstract
ALTHOUGH incubation time is a key parameter of the epidemiology of AIDS, statistical estimates based on transfusion-associated AIDS cases have, up to now, used only the single dataset provided by the AIDS program of the Centers for Disease Control (CDC) in Atlanta. Using a k.ew dataset provided by the Direction Générale de la Santé (DGS) of the French Ministry of Health1, we estimate the mean incubation time for AIDS (median in brackets) to be 5.3 years (5.3 years) with a 90% confidence interval ranging from 4.4 to 8.9 years (4.4 to 8.8 years), when a Weibull distribution is postulated for incubation time. The previously encountered problem of very large confidence intervals (range larger than 100 years)2, is not observed, indicating that an accurate estimate for mean incubation time will be obtainable in the near future.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Reidiboym, M., Laporte, A. & Brunet, J. B. Bull. Epidémiologique Hebdomadaire 22, 85–86 (1988).
Kalbfleish, J. D. & Lawless, J. F. Nature 333, 504–505 (1988).
WHO Wkly Épidem. Rec. 63, 309–310 (1988).
WHO Wkly Épidem. Rec. 63, 1–7 (1988).
Medley, G. F., Anderson, R. M., Cox, D. R. & Billard, L. Nature 328, 719–721 (1987).
Medley, G. F., Billard, L., Cox, D. R. & Anderson, R. M. Proc. R. Soc. B233, 367–377 (1988).
Lui, K. J. et al. Proc. natn. Acad. Sci. U.S.A. 83, 3051–3055 (1986).
Lui, K. J., Peterman, T. A., Lawrence, D. N. & Allen J. R. Statist. Med. 7, 395–401 (1988).
Kalbfleish, J. D., Lawless, J. F. J. R. statist. Soc. A151, 47–48 (1988).
Kalbfleish, J. D. & Prentice, R. L. The Statistical Analysis of Failure Time Data (Wiley, New York, 1980).
Medley, G. F., Anderson, R. M., Cox, D. R. & Billard, L. Nature 333, 505 (1988).
Anderson, R. M. & Medley, G. F. AIDS 2 (Suppl. 1), S57–S63 (1988).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Costagliola, D., Mary, JY., Brouard, N. et al. Incubation time for AIDS from French transfusion-associated cases. Nature 338, 768–769 (1989). https://doi.org/10.1038/338768a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/338768a0
This article is cited by
-
Infections and immunological hazards of allogeneic bone transplantation
Archives of Orthopaedic and Trauma Surgery (1995)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
