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Activation and repression of transcription by homoeodomain-containing proteins that bind a common site

Nature volume 336, pages 744–749 (1988)Cite this article

Abstract

The product of the fushi tarazu (ftz) gene is shown to be a site-dependent activator of transcription. In vitro-defined binding sites act as ftz-dependent enhancers in cultured cells. Another homoeodomain-containing protein, the engrailed gene product, competes for homoeodomain-binding sites and counteracts ftz activation.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, 94143, USA

    James B. Jaynes & Patrick H. O'Farrell

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  1. James B. Jaynes
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  2. Patrick H. O'Farrell
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Jaynes, J., O'Farrell, P. Activation and repression of transcription by homoeodomain-containing proteins that bind a common site. Nature 336, 744–749 (1988). https://doi.org/10.1038/336744a0

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