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Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

Nature volume 336, pages 738–744 (1988)Cite this article

Abstract

cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site ofcdc2 tyrosine phosphorylation in vivo W selectively phosphorylated by pp60c–src in vitro.

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York, 11724, USA

    Giulio Draetta & David Beach

  2. Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Helen Piwnica-Worms, Deborah Morrison, Brian Druker & Thomas Roberts

Authors
  1. Giulio Draetta
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  2. Helen Piwnica-Worms
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  3. Deborah Morrison
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  4. Brian Druker
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  5. Thomas Roberts
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  6. David Beach
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Draetta, G., Piwnica-Worms, H., Morrison, D. et al. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature 336, 738–744 (1988). https://doi.org/10.1038/336738a0

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