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Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree

Nature volume 336, pages 167–170 (1988)Cite this article

Abstract

Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode of inheritance1–6. The discovery of genetic aetiologic factors and resolution of the inheritance pattern(s) will undoubtably emerge from genetic linkage studies. With these objectives in mind, we undertook a linkage project, starting in 1985, in a previously well-documented kindred from north Sweden. Multipoint linkage analyses were used to screen the proximal long arm of chromosome 5 using restriction fragment length polymorphism (RFLP) markers at five loci and the distal long arm using RFLPs at two loci, one of which was the locus for the glucocorticoid receptor. We found strong evidence against linkage between schizophrenia and the seven loci. These results, together with the positive evidence7 for linkage of schizophrenia with markers in the proximal long arm of chromosome 5 lead us to conclude that the genetic factors underlying schizophrenia are heterogeneous.

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References

  1. Kidd, K. K. & Cavalli-Sforza, L. L. Soc. Biol. 20, 254–256 (1973).

    Article  CAS  Google Scholar 

  2. Matthysse, S. W. & Kidd, K. K. Am. J. Psychiat. 133, 185–192 (1976).

    Article  CAS  Google Scholar 

  3. McGue, M., Gottesman, I. I. & Rao, D. C. Am. J. hum. Genet. 35, 1161–1178 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Baron, M. & Risch, N. J. Psychiat. Res. 21, 257–267 (1987).

    Article  CAS  Google Scholar 

  5. Kendler, K. S. in Relatives at Risk for Mental Disorder (eds Dunner, D. L., Gershon, G. S. & Barrett, J. E.) 247–266 (Raven, New York, 1988).

    Google Scholar 

  6. Karlsson, J. L., Br. J. Psychiat. 152, 324–329 (1988).

    Article  CAS  Google Scholar 

  7. Sherrington, R. et al. Nature 336, 164–167 (1988).

    Article  ADS  CAS  Google Scholar 

  8. Book, J. A. Acta genet. 4, 1–100 (1953).

    CAS  PubMed  Google Scholar 

  9. Book, J. A., Wetterberg, L. & Modrzewska, K. Clin. Genet. 14, 373–394 (1978).

    Article  CAS  Google Scholar 

  10. Feighner, J. P. et al. Archs gen. Psychiat 26, 57–63 (1972).

    Article  CAS  Google Scholar 

  11. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-III) 3rd edn (Washington, DC, 1980).

  12. Bassett, A. S., Jones, B. D., McGillivray, B. C. & Pantzar, J. T. Lancet i, 799–801 (1988).

    Article  Google Scholar 

  13. Weinberger, C. et al. Cytogenet. Cell Genet. 40, 776 (1985).

    Google Scholar 

  14. Carroll, B. J. et al. Archs gen. Psychiat. 38, 15–22 (1981).

    Article  CAS  Google Scholar 

  15. Hall, R. C. W., Popkin, M. K., Stickney, S. K. & Gardner, E. R. J. nerv. ment. Dis. 167, 229–236 (1979).

    Article  CAS  Google Scholar 

  16. Giuffra, L. A. et al. Cytogenet. Cell Genet. (in the press).

  17. Leppert, M. et al. Science 238, 1411–1413 (1987).

    Article  ADS  CAS  Google Scholar 

  18. Pakstis, A. J., Kidd, J. R., Castiglione, C., Sparkes, R. S. & Kidd, K. K. Cytogenet. Cell Genet. 41, 189–190 (1986).

    Article  CAS  Google Scholar 

  19. Lathrop, G. M., Lalouel, J. M., Julier, C. & Ott, J. Proc. natn. Acad. Sci. U.S.A. 81, 3443–3446 (1984).

    Article  ADS  CAS  Google Scholar 

  20. Lathrop, G. M., Lalouel, J. M., Julier, C. & Ott, J. Am. J. hum. Genet. (1985).

  21. Wood, S. et al. Genome 30 abstract 32.35.9. (1988).

  22. Anderson, M. A. & Gusella, J. F. In Vitro 20, 856 (1984).

    Article  CAS  Google Scholar 

  23. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. Kenneth K. Kidd: To whom correspondence should be addressed.

Authors and Affiliations

  1. Departments of Human Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06511, USA

    James L. Kennedy, Andrew J. Pakstis, Judith R. Kidd, Carmela M. Castiglione & Kenneth K. Kidd

  2. Departments of Psychiatry, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06511, USA

    James L. Kennedy & Kenneth K. Kidd

  3. Departments of Section of Neuroanatomy, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06511, USA

    Luis A. Giuffra

  4. Department of Genetics, Stanford University School of Medicine, Stanford, California, 94305, USA

    Hans W. Moises & L. L. Cavalli-Sforza

  5. Department of Psychiatry, Karolinska Institute, St Goran's Hospital, Box 12500, 112 81, Stockholm, Sweden

    Barbro Sjogren & Lennart Wetterberg

Authors
  1. James L. Kennedy
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  2. Luis A. Giuffra
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  4. L. L. Cavalli-Sforza
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  5. Andrew J. Pakstis
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  6. Judith R. Kidd
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  7. Carmela M. Castiglione
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  8. Barbro Sjogren
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  9. Lennart Wetterberg
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  10. Kenneth K. Kidd
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Kennedy, J., Giuffra, L., Moises, H. et al. Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 336, 167–170 (1988). https://doi.org/10.1038/336167a0

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