Abstract
The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression ofpp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.
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Sagata, N., Oskarsson, M., Copeland, T. et al. Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes. Nature 335, 519–525 (1988). https://doi.org/10.1038/335519a0
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DOI: https://doi.org/10.1038/335519a0
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