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Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

Nature volume 335, pages 519–525 (1988)Cite this article

Abstract

The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression ofpp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.

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Authors and Affiliations

  1. Bionetics Research Inc., National Cancer Institute, PO Box B, Frederick, Maryland, 21701, USA

    Noriyuki Sagata, Marianne Oskarsson, Terry Copeland & George F. Vande Woude

  2. School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, 68588, USA

    John Brumbaugh

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  1. Noriyuki Sagata
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  2. Marianne Oskarsson
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  3. Terry Copeland
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  4. John Brumbaugh
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  5. George F. Vande Woude
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Sagata, N., Oskarsson, M., Copeland, T. et al. Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes. Nature 335, 519–525 (1988). https://doi.org/10.1038/335519a0

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