Abstract
Associations between short amino acid sequence patterns and protein secondary structure classes can be found by searching a data base of known protein structures. Analysis of these associations suggests that secondary structure of proteins can be determined locally by sequence motifs of high predictive value, but at present our ability to find these motifs is limited by the size of the available data bases.
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References
Chou, P. Y. & Fasman, G. D. Biochemistry 13, 222–245 (1974).
Garnier, J., Osguthorpe, D. J. & Robson, B. J. molec. Biol. 120, 97–120 (1978).
Gibrat, J.-F., Garnier, J. & Robson, B. J. molec. Biol. 198, 425–443 (1987).
Finkelstein, A. V. & Ptitsyn, O. B. J. molec. Biol. 62, 613–624 (1971).
Lim, V. I. J. molec. Biol. 88, 873–894 (1974).
Kabsch, W. & Sander, C. FEBS Lett. 155, 179–182 (1983).
Sibanda, B. L. & Thornton, J. M. Nature 316, 170–174 (1985).
Edwards, M. S., Sternberg, M. J. E. & Thornton, J. M. Protein Engineering 1, 173–181 (1987).
Wierenga, R. K., De Maeyer, M. C. H. & Hol, W. G. J. Biochemistry 24, 1346–1357 (1985).
Taylor, W. R. & Thornton, J. M. J. molec. Biol. 173, 487–514 (1984).
Cohen, F. E., Abarbanel, R. M., Kuntz, I. D. & Fletterick, R. J. Biochemistry 25, 266–275 (1986).
Stone, M. J. R. Statist. Soc. Series B. 36, 111–147 (1974).
Rescher, N. & Urquart A. Temporal Logic (Springer, Berlin, 1971).
Bernstein, F. C. et al. J. molec. Biol. 112, 535–542 (1977).
Kabsch, W. & Sander, C. Biopolymers 22, 2577–2637 (1983).
Crawford, J. L., Lipscomb, M. N. & Schellman, C. G. Proc. natn. Acad. Sci. U.S.A. 70, 538–542 (1973).
Cohen, F. E., Abarbanel, R. M., Kuntz, I. D. & Fletterick, R. J. Biochemistry 22, 4894–4904 (1983).
Kabsch, W. & Sander, C. Proc. natn. Acad. Sci. U.S.A. 81, 1075–1078 (1984).
Blundell, T. L., Sibanda, B. L., Sternberg, M. J. E. & Thornton, J. M. Nature 326, 347–352 (1987).
Jones, T. A. & Thirup, T. EMBO J. 5, 819–822 (1986).
Kraulis, P. J., & Jones, T. A. Proteins 2, 188–201 (1987).
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Rooman, M., Wodak, S. Identification of predictive sequence motifs limited by protein structure data base size. Nature 335, 45–49 (1988). https://doi.org/10.1038/335045a0
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DOI: https://doi.org/10.1038/335045a0
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