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Transcriptional autoregulation of the proto-oncogene fos

Abstract

Serum-induced transcription of the proto-oncogene fos is under negative feedback regulation mediated by the fos protein. The fos promoter region responsive to repression is also required for serum inducibility and binds a nucleoprotein complex in which the nuclear factor AP-1 is associated with fos protein.

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Sassone-Corsi, P., Sisson, J. & Verma, I. Transcriptional autoregulation of the proto-oncogene fos. Nature 334, 314–319 (1988). https://doi.org/10.1038/334314a0

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