Abstract
Serum-induced transcription of the proto-oncogene fos is under negative feedback regulation mediated by the fos protein. The fos promoter region responsive to repression is also required for serum inducibility and binds a nucleoprotein complex in which the nuclear factor AP-1 is associated with fos protein.
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References
Dynan, W. S. & Tjian, R. Nature 316, 774–778 (1985).
Sassone-Corsi, P. & Borrelli, E. Trends Genet. 2, 215–219 (1986).
Jones, N. C., Rigby, P. W. J. & Ziff, E. B. Genes Devl. 2, 267–281 (1988).
Wingender, E. Nucleic Acids Res. 16, 1879–1902 (1988).
Bohmann, D. et al. Science 238, 1386–1392 (1987).
Angel, P. et al. Nature 332, 166–171 (1988).
Sap, J. et al Nature 324, 635–640 (1986).
Weinberger, C. et al. Nature 324, 641–646 (1986).
Holt, J. T., Venkat Gopal, T., Moulton, A. D. & Nienhuis, A. W. Proc. natn. Acad. Sci. U.S.A 83, 4794–4798 (1986).
Nishikura, K. & Murray, J. M. Molec. cell. Biol. 7, 639–649 (1987).
Muller, R. & Wagner, E. Nature 311, 438–442 (1984).
Distel, R. J., Ro, H.-S., Rosen, B. S., Groves, D. L. & Speigelman, B. M. Cell 49, 835–844 (1987).
Ruther, U., Garber, C., Komitowski, D., Muller, R. & Wagner, E. F. Nature 325, 412–416 (1987).
Dony, C. & Gruss, P. Nature 328, 711–714 (1987).
Verma, I. M. & Graham, W. R. Adv. Cancer Res. 49, 29–52 (1987).
Verma, I. M. Trends Genet. 2, 93–96 (1986).
Rauscher, F. J. III, Sambucetti, L. C., Curran, T., Distel, E. J. & Speigelman, B. M. Cell 52, 471–480 (1988).
Sassone-Corsi, P., Lamph, W. W., Kamps, M. & Verma, I. M. Cell (in the press).
Franza, R. B., III, Rauscher, F. J. III, Josephs, S. F. & Curran, T. Science 239, 1150–1153 (1988).
Setoyama, C., Frunzio, R., Lian, G., Mudryi, M. & De Crombrugghe, B. Proc. natn. Acad. Sci. U.S.A. 83, 3213–3217 (1986).
Lech, K., Anderson, K. & Brent, R. Cell 52, 179–184 (1988).
Vogt, P., Bos, T. J. & Doolittle, R. F. Proc. natn. Acad. Sci. U.S.A. 84, 3316–3319 (1987).
Greenberg, M. E. & Ziff, E. B. Nature 311, 433–438 (1984).
Greenberg, M. E., Hermanowski, A. L. & Ziff, E. B. Molec. cell. Biol. 6, 1050–1057 (1986).
Mitchell, R. L., Henning-Chubb, C., Huberman, E. & Verma, I. M. Cell 45, 497–504 (1986).
Miller, A. D., Curran, T. & Verma, I. M. Cell 36, 51–60 (1984).
Gilman, M., Wilson, R. N. & Weinberg, R. A. Molec. cell. Biol. 6, 4305–4316 (1986).
Greenberg, M. E., Siegfried, Z. & Ziff, E. B. Molec. cell. Biol. 7, 1217–1225 (1987).
Treisman, R. EMBO J. 6, 2711–2717 (1987).
Treisman, R. Cell 46, 567–574 (1986).
Hayes, T. E., Kitchen, A. M. & Cochran, B. H. Proc. natn. Acad. Sci. U.S.A. 84, 1272–1276 (1987).
Sassone-Corsi, P. & Borrelli, E. Proc. natn. Acad. Sci. U.S.A. 84, 6430–6433 (1987).
Treisman, R. Cell 42, 889–902 (1985).
Wu, B. J. & Morimoto, R. I. Proc. natn. Acad. Sci. U.S.A. 82, 6070–6074 (1985).
Angel, P. et al. Cell 49, 729–739 (1987).
Fisch, T. M., Prywes, R. & Roeder, R. G. Molec. cell. Biol. 7, 3490–3502 (1987).
Curran, T., Van Beveren, C., Ling, N. & Verma, I. M. Molec. cell. Biol. S 107–112 (1985).
Giguere, V., Hollenberg, S. M., Rosenfeld, M. G. & Evans, R. M. Cell 46, 645–652 (1986).
Gurney, E. G., Harrison, R. O. & Fenno, J. J. Virol. 34, 752–763 (1980).
Verma, I. M. & Sassone-Corsi, P. Cell 51, 513–514 (1987).
Cochran, B. H., Reffel, A. C. & Stiles, C. D. Cell 33, 939–947 (1983).
Kruijer, W., Cooper, J. A., Hunter, T. & Verma, I. M. Nature 312, 711–716 (1984).
Muller, R., Bravo, R., Burckhardt, J. & Curran, T. Nature 312, 716–720 (1984).
Sassone-Corsi, P. & Verma, I. M. Nature 326, 507–510 (1987).
Lau, L. F. & Nathans, D. Proc. natn. Acad. Sci. U.S.A. 84, 1182–1186 (1987).
Ryder, K., Lau, L. F. & Nathans, D. Proc. natn. Acad. Sci. U.S.A. 85, 1487–1491 (1988).
Sambuccetti, L. & Curran, T. Science 234, 1417–1419 (1986).
Renz, M., Vermier, B., Jurz, C. & Muller, R. Nucleic Acids Res. 15, 277–293 (1987).
Rauscher, F. J. III et al. Science 240, 1010–1016 (1988).
Curran, T., Miller, A. D., Zokas, L. & Verma, I. M. Cell 36, 259–268 (1984).
Barber, J. & Verma, I. M. Molec. cell Biol. 7, 2201–2211 (1987).
Lillie, J. W., Green, M. & Green, M. R. Cell 46, 1043–1051 (1986).
Van Straaten, F., Muller, R., Curran, T., Van Beveren, C. & Verma, I. M. Proc. natn. Acad. Sci. U.S.A. 80, 3183–3187 (1983).
Deschamps, J., Meijlink, F. & Verma, I. M. Science 230, 1174–1177 (1985).
Gorman, C., Moffat, L. F. & Howard, B. H. Molec. cell. Biol. 2, 1044–1051 (1982).
Meijlink, F., Curran, T., Miller, A. D. & Verma, I. M. Proc. natn. Acad. Sci. U.S.A. 82, 4987–4991 (1985).
Verma, I. M. et al. Gene Transfer in Animals (UCLA Symposium, in the press).
De Togni, P., Niman, H., Raymond, V., Sawchenko, P. & Verma, I. M. Molec. cell. Biol. (in the press).
Ishii, S., Merlino, G. & Pastan, I. Science 230, 1378–1381 (1985).
Dignam, J. D., Lebovitz, R. M. & Roeder, R. Nucleic Acids Res. 11, 1475–1489 (1983).
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Sassone-Corsi, P., Sisson, J. & Verma, I. Transcriptional autoregulation of the proto-oncogene fos. Nature 334, 314–319 (1988). https://doi.org/10.1038/334314a0
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DOI: https://doi.org/10.1038/334314a0
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