Abstract
Some wild African green monkeys are known to be naturally infected with a retrovirus related to human immunodeficiency virus (HIV) without having any apparent symptoms of an AIDS-Iike disease1,2. This simian immunodeficiency virus, designated SIVAGM, may be helpful in clarifying the evolution and pathogenic-ity of HIV. Some virus strains that were previously reported to be isolated from African green monkeys3–5 were shown to be labora-tory contaminations of SIVMAC (SIV from a rhesus macaque)6–8. Here we report the complete DNA sequence of authentic SIVAGM, which was isolated from a naturally infected African green monkey of Kenyan origin. Comparison of the genome of SIVAGM with those of known HIV/SIVs indicates that the virus is a new simian lentivirus that is approximately equally distantly related to HIV-1 and HIV-2 in contrast to SIVMAC, which is much closer to HIV-2 than to HIV-1 (refs 5, 9).
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References
Kanki, P. J., Alroy, J. & Essex, M. Science 230, 951–954 (1985).
Ohta, Y. et al. Int. J. Cancer 41, 115–122 (1988).
Hirsch, V. et al. Proc. natn. Acad. Sci. U.S.A. 83, 9754–9758 (1986).
Hirsch, V., Riedel, N. & Mullins, J. I. Cell 49, 307–319 (1987).
Franchini, G. et al. Nature 328, 539–543 (1987).
Newmark, P. Nature 326, 548 (1987).
Desrosiers, R. C., Daniel, M. D., Letvin, N. L. & Hunt, R. D. Nature 327, 107 (1987).
Kestler III, H. W. et al. Nature 331, 619–621 (1988).
Chakrabarti, L. et al. Nature 328, 543–547 (1987).
Wain-Hobson, S., Sonigo, P., Danos, O., Cole, S. & Alizon, M. Cell 40, 9–17 (1985).
Ratner, L. et al. Nature 313, 277–284 (1985).
Muesing, M. A. et al. Nature 313, 450–458 (1985).
Sanchez-Pescador, R. et al. Science 227, 484–492 (1985).
Alizon, M., Wain-Hobson, S., Montagnier, L. & Sonigo, P. Cell 46, 63–74 (1986).
Guyader, M. et al. Nature 326, 662–669 (1987).
Kornfeld, K., Riedel, N., Vigilanti, G. A., Hirsch, V. & Mullins, J. I. Nature 326, 610–613 (1987).
Nabel, O. & Baltimore, D. Nature 326, 711–713 (1987).
Jones, K. A., Kadonaga, J. T., Luciw, P. A. & Tjian, R. Science 232, 755–759 (1986).
Casey, J. M. et al. J. Virol. 55, 417–423 (1985).
Lightfoote, M. M. et al. J. Virol. 60, 771–775 (1986).
Kowalski, M. et al. Science 237, 1351–1355 (1987).
Gallaher, W. R. Cell 50, 327–328 (1987).
Guy, B. et al. Nature 330, 266–269 (1987).
Wong-Staal, F. et al. Science 229, 759–762 (1985).
Clavel, F. et al. Nature 324, 691–695 (1986).
Komuro, A. et al. Virology 138, 373–378 (1984).
Hayami, M. Cancer Rev. 1, 35–63 (1986).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.SA. 74, 5463–5467 (1977).
Wilbur, W. J. & Lipman, D. J. Proc. natn. Acad. Sci. U.S.A. 80, 726–730 (1983).
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Fukasawa, M., Miura, T., Hasegawa, A. et al. Sequence of simian immunodeficiency virus from African green monkey, a new member of the HIV/SIV group. Nature 333, 457–461 (1988). https://doi.org/10.1038/333457a0
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DOI: https://doi.org/10.1038/333457a0
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