Abstract
The T-cell receptor δ-chain variable region can be assembled from as many as four distinct gene segments, V, D1 D2 and J, more than any other antigen-receptor gene. In fetal thymocytes V → D joinings are as common as D → J or VDJ rearrangements and one V gene segment predominates. Analysis of rearrangements at TCR γ and δ loci during fetal ontogeny suggests abrupt changes and possible coordinate control in the rearrangement and expression of these loci.
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Chiei, Yh., Iwashima, M., Wettstein, D. et al. T-cell receptor δ gene rearrangements in early thymocytes. Nature 330, 722–727 (1987). https://doi.org/10.1038/330722a0
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DOI: https://doi.org/10.1038/330722a0
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