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Different H–2 subregions influence immunization against retrovirus and immunosuppression

Nature volume 329, pages 729–732 (1987)Cite this article

Abstract

Friend murine leukaemia virus complex (FV) causes an immunosuppressive retrovirus-induced disease. In certain mouse strains, FV shows striking similarities to human immunodeficiency virus (HIV) infection in man in that infected mice have severe T-cell immunosuppression but also develop virus-neutralizing antibodies incapable of eliminating infected cells. Previously we noted the influence of mouse major histocompatibility complex (H–2) genes on both FV-induced immunosuppression1 and on ability to protect mice against FV by immunizing with a vaccinia–Friend murine leukaemia helper virus (F-MuLV) envelope (env) recombinant virus2. Here we show that different subregions of H–2 are involved in susceptibility to virus-induced immunosuppression (H–2D subregion) and protective immunization with a recombinant vaccinia virus (H–2K or I–A subregions). Thus, susceptibility to virus-induced immunosuppression does not preclude protection by vaccinia–Friend immunization. The mechanism of protection seems to involve priming of immune T cells, and not initial induction of neutralizing antibodies or cytotoxic T lymphocytes (CTL) (ref. 2). Subsequent virus challenge generates a secondary response, resulting in appearance of IgG antibodies and CTL. In human HIV infection there could also be host genetic influences on elements of disease pathogenesis, such as immunosuppression, and on the success of T-cell priming by potential protective vaccines.

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References

  1. Morrison, R. P., Nishio, J. & Chesebro, B. J. exp. Med. 163, 301–314 (1986).

    Article  CAS  Google Scholar 

  2. Earl, P. L. et al. Science 234, 728–731 (1986).

    Article  ADS  CAS  Google Scholar 

  3. Teich, N., Wyke, J., Mak, T., Bernstein, A. & Hardy, W. in RNA Tumor Viruses, Molecular Biology of Tumor Viruses (eds Weiss, R., Teich, N., Varmus, H. & Coffin, J.) 785–998 (Cold Spring Harbor Laboratory, New York, 1984).

    Google Scholar 

  4. Chesebro, B. & Wehrly, K. J. exp. Med. 143, 73–84 (1976).

    Article  CAS  Google Scholar 

  5. Chesebro, B., Bloom, M., Wehrly, K. & Nishio, J. J. Virol. 32, 832–837 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Doig, D. & Chesebro, B. J. exp. Med. 150, 10–19 (1979).

    Article  CAS  Google Scholar 

  7. Chesebro, B. & Wehrly, K. Proc. natn. Acad. Sci. U.S.A. 76, 425–429 (1979).

    Article  ADS  CAS  Google Scholar 

  8. Doig, D. & Chesebro, B. J. exp. Med. 148, 1109–1121 (1978).

    Article  CAS  Google Scholar 

  9. Chesebro, B., Wehrly, K., Doig, D. & Nishio, J. Proc. natn. Acad. Sci. U.S.A. 76, 5784–5788 (1979).

    Article  ADS  CAS  Google Scholar 

  10. Weiss, R. A. et al. Nature 316, 69–72 (1985).

    Article  ADS  CAS  Google Scholar 

  11. Robert-Guroff, M., Brown, M. & Gallo, R. C. Nature 316, 72–74 (1985).

    Article  ADS  CAS  Google Scholar 

  12. McDougal, J. S. et al. J. Immunol. Meth. 76, 171–183 (1985).

    Article  CAS  Google Scholar 

  13. Essex, M. et al. Science 220, 859–862 (1983).

    Article  ADS  CAS  Google Scholar 

  14. Lane, H. C. & Fauci, A. S. A. Rev. Immun. 3, 477–500 (1985).

    Article  CAS  Google Scholar 

  15. Rook, A. H. et al. J. Immun. 138, 1064–1067 (1987).

    CAS  PubMed  Google Scholar 

  16. Cremer, K. J., Mackett, M., Wohlenberg, C., Notkins, A. L. & Moss, B. Science 228, 737–740 (1985).

    Article  ADS  CAS  Google Scholar 

  17. Green, I., Paul, W. E. & Benacerraf, B. J. J. exp. Med. 123, 859–879 (1966).

    Article  CAS  Google Scholar 

  18. McDevitt, H. O. J. Immun. 100, 485–492 (1968).

    CAS  Google Scholar 

  19. Chesebro, B., Wehrly, K. & Stimpfling, J. J. exp. Med. 140, 1457–1467 (1974).

    Article  CAS  Google Scholar 

  20. Britt, W. J. & Chesebro, B. J. exp. Med. 157, 1736–1745 (1983).

    Article  CAS  Google Scholar 

  21. Smith, G. L., Murphy, B. R. & Moss, B. Proc. natn. Acad. Sci. U.S.A. 80, 7155–7159 (1983).

    Article  ADS  CAS  Google Scholar 

  22. Chesebro, B., Britt, W., Evans, L., Wehrly, K., Nishio, J. & Cloyd, M. Virology 127, 134–148 (1983).

    Article  CAS  Google Scholar 

  23. Wolfe, J. H., Blank, K. J. & Pincus, T. Immunogenetics 12, 187–190 (1981).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Persistent Viral Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, 59840, USA

    Richard P. Morrison, Jane Nishio, Donald L. Lodmell & Bruce Chesebro

  2. Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Patricia L. Earl & Bernard Moss

Authors
  1. Richard P. Morrison
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  2. Patricia L. Earl
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  3. Jane Nishio
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  4. Donald L. Lodmell
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  5. Bernard Moss
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  6. Bruce Chesebro
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Morrison, R., Earl, P., Nishio, J. et al. Different H–2 subregions influence immunization against retrovirus and immunosuppression. Nature 329, 729–732 (1987). https://doi.org/10.1038/329729a0

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