Abstract
A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.
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Sette, A., Buus, S., Colon, S. et al. Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells. Nature 328, 395–399 (1987). https://doi.org/10.1038/328395a0
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DOI: https://doi.org/10.1038/328395a0
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