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A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

Nature volume 327, pages 677–682 (1987)Cite this article

Abstract

A new T-cell receptor gene lies just 5' to the JαCα coding regions. Its placement in this location suggests a novel mechanism for the regulation of expression of one T-cell receptor polypeptide to another during ontogeny. Rearrangement of this locus occurs very early in thymic differentiation and its RNA expression parallels that of the γ-chain in thymic subpopulations, making this a possible candidate for the recently described δ-chain of the T-cell receptor.

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Authors and Affiliations

  1. Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California, 94305, USA

    Yueh-hsiu Chien, Makio Iwashima, Kenneth B. Kaplan, John F. Elliott & Mark M. Davis

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  1. Yueh-hsiu Chien
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  2. Makio Iwashima
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  4. John F. Elliott
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Chien, Yh., Iwashima, M., Kaplan, K. et al. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. Nature 327, 677–682 (1987). https://doi.org/10.1038/327677a0

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