Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes

Abstract

Cloned blood lymphocytes that do not express the α- and β-chains of the T-cell receptor show MHC-unrestricted cytotoxicity. These cells carry the γ-protein, disulphide-linked either to another molecule or to itself, and associated with the CD3 complex. These observations may help to solve the mystery posed by the discovery of the γ gene.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Allison, J. P., Mclntyre, B. W. & Bloch, D. J. J. Immun. 129, 2293–2300 (1982).

    CAS  PubMed  Google Scholar 

  2. Haskins, K. et al. J. exp. Med. 157, 1149–1169 (1983).

    Article  CAS  PubMed  Google Scholar 

  3. Meuer, S. C. et al. J. exp. Med. 157, 705–719 (1983).

    Article  CAS  PubMed  Google Scholar 

  4. Yanagi, Y. et al. Nature 308, 145–149 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Hedrick, S. M., Cohen, D. I., Nielsen, E. A. & Davis, M. M. Nature 308, 149–153 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Saito, H. et al. Nature 309, 757–762 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Acuto, O. et al. Cell 34, 717–725 (1983).

    Article  CAS  PubMed  Google Scholar 

  8. Kappler, J. W. et al. Cell 35, 295–302 (1983).

    Article  CAS  PubMed  Google Scholar 

  9. Mclntyre, B. W. & Allison, J. P. Cell 34, 739–746 (1983).

    Article  Google Scholar 

  10. Kronenberg, M., Siu, G., Hood, L. & Shastri, N. A. Rev. Immun. 4, 529–591 (1986).

    Article  CAS  Google Scholar 

  11. Reinherz, E. L. et al. Cell 30, 735–743 (1982).

    Article  CAS  PubMed  Google Scholar 

  12. Borst, J., Alexander, S., Elder, J. & Terhorst, C. J. biol. Chem. 258, 5135–5141 (1983).

    CAS  PubMed  Google Scholar 

  13. Oettgen, H. C., Kappler, J., Tax, W. J. M. & Terhorst, C. J. biol Chem. 259, 12039–12048 (1984).

    CAS  PubMed  Google Scholar 

  14. Brenner, M. B., Trowbridge, I. & Strominger, J. L. Cell 40, 183–190 (1985).

    Article  CAS  PubMed  Google Scholar 

  15. Borst, J. et al. Nature 312, 455–458 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Weiss, A. & Stobo, J. D. J. exp. Med. 160, 1284–1299 (1984).

    Article  CAS  PubMed  Google Scholar 

  17. Ohashi, P. S. et al. Nature 316, 606–609 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Weiss, A. et al. A. Rev. Immun. 4, 593–619 (1986).

    Article  CAS  Google Scholar 

  19. Heilig, J. S. et al. Nature 317, 68–70 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Zauderer, M., Iwamoto, A. & Mak, T. W. J. exp. Med. 163, 1314–1318 (1986).

    Article  CAS  PubMed  Google Scholar 

  21. Hayday, A. C. et al. Cell 40, 259–269 (1985).

    Article  CAS  PubMed  Google Scholar 

  22. Kranz, D. M. et al. Nature 313, 752–755 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  23. Murre, C. et al. Nature 316, 549–552 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Le Franc, M.-P., Forster, A., Baer, R., Stinson, M. A. & Rabbitts, T. H. Cell 45, 237–246 (1986).

    Article  CAS  Google Scholar 

  25. Lefranc, M.-P. & Rabbitts, T. H. Nature 316, 464–466 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Quertermous, T. et al. Science 231, 252–255 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  27. Quertermous, T. et al. Nature 322, 184–187 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Dialynas, D. et al. Proc. natn. Acad. Sci. U.S.A. 83, 2619–2623 (1986).

    Article  ADS  CAS  Google Scholar 

  29. Snodgrass, H. R., Dembic, Z., Steinmetz, M. & Von Boehmer, H. Nature 315, 232–233 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  30. Raulet, D. H., Garman, R. D., Saito, H. & Tonegawa, S. Nature 314, 103–107 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Sangster, R. N. et al. J. exp. Med 163, 1491–1508 (1986).

    Article  CAS  PubMed  Google Scholar 

  32. Brenner, M. B. et al. Nature 322, 145–149 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  33. Bank, I. et al. Nature 322, 179–181 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  34. Van de Griend, R. J. et al. Clin. Immun. Immunopath. 21, 94–106 (1981).

    Article  CAS  PubMed  Google Scholar 

  35. Van de Griend, R. J. et al. Immunology 47, 313–320 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  36. De la Hera, A., Toribio, M. L., Marquez, C. & Martinez-A, C. Proc. natn. Acad. Sci. U.S.A. 82, 6268–6271 (1985).

    Article  ADS  CAS  Google Scholar 

  37. Van de Griend, R. J. & Bolhuis, R. L. H. Blood 65, 1002–1009 (1985).

    CAS  PubMed  Google Scholar 

  38. Spits, H. et al. J. Immun. 135, 1922–1928 (1985).

    CAS  PubMed  Google Scholar 

  39. Lanier, L. L., Kipps, T. J. & Phillips, J. H. J. exp. Med. 162, 2089–2106 (1985).

    Article  CAS  PubMed  Google Scholar 

  40. Van de Griend, R. J., Giphart, M. J., Van Krimpen, B. A. & Bolhuis, R. L. H. J. Immun. 133, 1222–1228 (1984).

    CAS  PubMed  Google Scholar 

  41. Van de Griend, R. J. et al. J. Immun. 138, 1987.

  42. Spits, H., Yssel, H., Leeuwenberg, J. & De Vries, J. E. Eur. J. Immun. 15, 88–91 (1985).

    Article  CAS  Google Scholar 

  43. Leeuwenberg, J. F. M., Spits, H., Tax, W. J. M. & Capel, P. J. A. J. Immun. 134, 3770–3775 (1985).

    CAS  PubMed  Google Scholar 

  44. Bolhuis, R. L. H. & Van de Griend, R. J. Cell Immun. 93, 46–57 (1985).

    Article  CAS  Google Scholar 

  45. Ritz, J. et al. Science 228, 1540–1543 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  46. Lanier, L. L., Cwirla, S., Federspiel, N. & Phillips, J. H. J. exp. Med. 163, 209–214 (1986).

    Article  CAS  PubMed  Google Scholar 

  47. Quertermous, T. et al. J. Immun. (in the press).

  48. Greenberg, J. M., Quertermous, T., Seidman, J. G. & Kersey, J. H. J. Immun. 137, 2043–2049 (1986).

    CAS  PubMed  Google Scholar 

  49. Van Dongen, et al. J. Immun. (in the press).

  50. Elder, J. H. & Alexander, S. Proc. natn. Acad. Sci. U.S.A. 79, 4540–4544 (1982).

    Article  ADS  CAS  Google Scholar 

  51. Nowill, A. et al. J. exp. Med 163, 1601–1606 (1986).

    Article  CAS  PubMed  Google Scholar 

  52. Furley, A. J. et al. Cell 46, 75–87 (1986).

    Article  CAS  PubMed  Google Scholar 

  53. Weiss, A., Newton, M. & Crommie, D. Proc. natn. Acad. Sci. U.S.A. 83, 6998–7002 (1986).

    Article  ADS  CAS  Google Scholar 

  54. Bolhuis, R. L. H., Gravekamp, C. & Van de Griend, R. J. Clin. Immun. Allergy 6, 29–90 (1986).

    CAS  Google Scholar 

  55. Tax, W. J. M., Willems, H. W., Reekers, P. P. M., Capel, P. J. A. & Koene, R. A. P. Nature 304, 445–447 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  56. Oettgen, H. C., Pettey, C., Maloy, W. L. & Terhorst, C. Nature 320, 272–275 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  57. O'Farrell, P. H. J. biol. Chem. 250, 4007–4021 (1975).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Borst, J., van de Griend, R., van Oostveen, J. et al. A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes. Nature 325, 683–688 (1987). https://doi.org/10.1038/325683a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/325683a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing