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Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid

Abstract

Embryos derived from bicoid (bcd) females lack head and thorax. Cytoplasmic transplantation experiments reveal that bcd+-dependent activity is localized at the anterior pole of wild-type embryos. The activity can induce anterior development in mutant embryos at any position along the antero-posterior axis and suppresses posterior development.

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References

  1. Hafen, E., Kuroiwa, A. & Gehring, W. J. Cell 37, 833–841 (1984).

    Article  CAS  Google Scholar 

  2. Ingham, P. W., Howard, K. R. & Ish-Horovicz, U. Nature 318, 439–445 (1985).

    Article  ADS  CAS  Google Scholar 

  3. Knipple, D. C., Seifert, E., Rosenberg, U. B., Preiss, A. & Jäckle, H. Nature 317, 40–44 (1985).

    Article  ADS  CAS  Google Scholar 

  4. Sander, K. Adv. Insect Physiol. 12, 125–238 (1976).

    Article  Google Scholar 

  5. Kalthoff, K. in Determinantns of Spatial Organization (eds Subtelney, S. & Konigsberg, I.R.) 97–126 (Academic, New York, 1979).

    Book  Google Scholar 

  6. Frohnhöfer, H. G., Lehmann, R. & Nüsslein-Volhard, C. J. Embryol. exp. Morph. (in the press).

  7. Boswell, R. E. & Mahowald, A. P. Cell 43, 97–104 (1985).

    Article  CAS  Google Scholar 

  8. Schüpbach, T. & Wieschaus, E. Wilhelm Roux Arch. Devl Biol. 195, 302–317 (1986).

    Article  Google Scholar 

  9. Lehmann, R. & Nüsslein-Volhard, C. Cell (in the press).

  10. Bull, A. L. J. exp. Zool. 161, 221–241 (1966).

    Article  Google Scholar 

  11. Nüsslein-Volhard, C. Wilhelm Roux Arch. Devl Biol. 183, 249–268 (1977).

    Article  Google Scholar 

  12. Mohler, D. & Wieschaus, E. Genetics 112, 803–822 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Campos-Ortega, J. A. & Hartenstein, V. The embryonic development of Drosophila melanogaster (Springer, Heidelberg, 1985).

    Book  Google Scholar 

  14. Schmidt, O., Zissler, D., Sander, K. & Kalthoff, K. Devl Biol. 46, 216–221 (1975).

    Article  CAS  Google Scholar 

  15. Frigerio, G., Burri, M., Bopp, D., Baumgartner, S. & Noll, M. Cell (in the press).

  16. Meinhardt, H. J. Cell Sci. Suppl. 4, 357–387 (1986).

    Article  CAS  Google Scholar 

  17. Martinez-Arias, A. & Lawrence, P. A. Nature 313, 639–642 (1985).

    Article  ADS  CAS  Google Scholar 

  18. Nüsslein-Volhard, C. & Wieschaus, E. Nature 287, 795–801 (1980).

    Article  ADS  Google Scholar 

  19. Wieschaus, E., Nüsslein-Volhard, C. & Kluding, H. Devl Biol. 104, 172–186 (1984).

    Article  CAS  Google Scholar 

  20. Lehmann, R. & Nüsslein-Volhard, C. Devl Biol. (in the press).

  21. Carroll, S. B. & Scott, M. P. Cell 45, 113–126 (1986).

    Article  CAS  Google Scholar 

  22. Ingham, P. W., Ish-Horowicz, D. & Howard, K. R. EMBO J. 5, 1659–1665 (1986).

    Article  CAS  Google Scholar 

  23. Meinhardt, H. J. Cell Sci. 23, 117–139 (1977).

    Google Scholar 

  24. Anderson, K. V. & Nüsslein-Volhard, C. Nature 311, 223–227 (1984).

    Article  ADS  CAS  Google Scholar 

  25. Lindsley, D. & Zimm, G. Dros. Inf. Serv. 62, 1–226 (1985).

    Google Scholar 

  26. Wakimoto, B. T., Turner, F. R. & Kaufman, T. C. Devl Biol. 102, 147–172 (1984).

    Article  CAS  Google Scholar 

  27. Jürgens, G., Wieschaus, E., Nüsslein-Volhard, C. & Kluding, H. Wilhelm Roux Arch. Devl Biol. 193, 283–295 (1984).

    Article  Google Scholar 

  28. Lohs-Schardin, M., Cremer, C. & Nüsslein-Volhard, C. Devl. Biol. 73, 239–255 (1979).

    Article  CAS  Google Scholar 

  29. Jürgens, G., Lehmann, R., Schardin, M. & Nüsslein-Volhard, C. Wilhelm Roux's Arch. Devl Biol. 195, 359–377 (1986).

    Article  Google Scholar 

  30. Lehmann, R. dissertation, Univ. of Tübingen (1985).

  31. Lindsley, D. & Sandler, L. Genetics 71, 157–184 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Zalokar, M. & Erk, I. J. microsc. Biol. Cell 25, 97–106 (1976).

    Google Scholar 

  33. Carroll, S. B., Winslow, G. M., Schüpbach, T. & Scott, M. P. Nature 322, 278–280 (1986).

    Article  ADS  Google Scholar 

Download references

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Frohnhöfer, H., Nüsslein-Volhard, C. Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid. Nature 324, 120–125 (1986). https://doi.org/10.1038/324120a0

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